Allosteric Modulation of Seven Transmembrane Spanning Receptors: Theory, Practice, and Opportunities for Central Nervous System Drug Discovery

Abstract

ADVERTISEMENT RETURN TO ISSUEPREVPerspectiveNEXTAllosteric Modulation of Seven Transmembrane Spanning Receptors: Theory, Practice, and Opportunities for Central Nervous System Drug DiscoveryBruce J. Melancon†‡§, Corey R. Hopkins†∥‡§, Michael R. Wood†∥‡§, Kyle A. Emmitte†∥‡§, Colleen M. Niswender†‡§, Arthur Christopoulos⊥, P. Jeffrey Conn†‡§, and Craig W. Lindsley*†∥‡§View Author Information† ‡ § †Department of Pharmacology, ‡Vanderbilt Center for Neuroscience Drug Discovery, and §Vanderbilt Specialized Chemistry Center (MLPCN), Vanderbilt University Medical Center, Nashville, Tennessee 37232, United States∥ Department of Chemistry, Vanderbilt University, Nashville, Tennessee 37232, United States⊥ Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences and Department of Pharmacology, Monash University, Melbourne, Australia*Phone: [phone]. Fax: [phone]. E-mail: [email protected]Cite this: J. Med. Chem. 2012, 55, 4, 1445–1464Publication Date (Web):December 9, 2011Publication History Received25 August 2011Published online6 January 2012Published inissue 23 February 2012https://pubs.acs.org/doi/10.1021/jm201139rhttps://doi.org/10.1021/jm201139rreview-articleACS PublicationsCopyright © 2011 American Chemical SocietyRequest reuse permissionsArticle Views7319Altmetric-Citations193LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Agonists,Ligands,Modulators,Polyacrylamide,Receptors Get e-Alerts