Concepedia

Allosteric Modulation Potency

Allosteric Modulation Potency is a pharmacological metric that quantifies the ability of an allosteric ligand to modulate the activity of a receptor protein at a site distinct from the orthosteric binding site, thereby altering the receptor's functional response to its primary agonist.

121

Publications

6.7K

Citations

805

Authors

152

Institutions

Publications per year

2017–2026

30

Parents

Publications

121

Cannabidiol is a negative allosteric modulator of the cannabinoid CB <sub>1</sub> receptor

Robert B. Laprairie, Amina M. Bagher, Michael E. Kelly et al. · British Journal of Pharmacology · 2015 · 1K citations · Full text

, , +13

Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety

Alex B. Burgin, Ólafur Þ. Magnússon, Jasbir Singh et al. · Nature Biotechnology · 2009 · 394 citations

, , +12

Allosteric Modulation of Seven Transmembrane Spanning Receptors: Theory, Practice, and Opportunities for Central Nervous System Drug Discovery

Bruce J. Melancon, Corey R. Hopkins, Michael R. Wood et al. · Journal of Medicinal Chemistry · 2011 · 223 citations · Full text

, , +17

ADX47273 [S-(4-Fluoro-phenyl)-{3-[3-(4-fluoro-phenyl)-[1,2,4]-oxadiazol-5-yl]-piperidin-1-yl}-methanone]: A Novel Metabotropic Glutamate Receptor 5-Selective Positive Allosteric Modulator with Preclinical Antipsychotic-Like and Procognitive Activities

Feng Liu, Steve Grauer, Cody Kelley et al. · Journal of Pharmacology and Experimental Therapeutics · 2008 · 182 citations

, , +17

Positive Allosteric Modulators of GluN2A-Containing NMDARs with Distinct Modes of Action and Impacts on Circuit Function

David H. Hackos, Patrick J. Lupardus, Teddy Grand et al. · Neuron · 2016 · 173 citations · Full text

, , +17

1–5 of 121

Authors

805

  1. PJ
    P. Jeffrey Conn

    Vanderbilt University, United States

    22 publications · 1.4K citations

    19

    h-index

  2. CW
    Craig W. Lindsley

    Vanderbilt University, United States

    17 publications · 1.2K citations

    15

    h-index

  3. CM
    Colleen M. Niswender

    Vanderbilt University, United States

    15 publications · 944 citations

    14

    h-index

  4. CK
    Carrie K. Jones

    Vanderbilt University, United States

    7 publications · 400 citations

    8

    h-index

  5. TM
    Thomas M. Bridges

    Vanderbilt University, United States

    7 publications · 395 citations

    8

    h-index

1–5 of 805

Institutions

152

  1. Vanderbilt University Medical Center

    Nashville, United States

    15 h-index

    114 publications

    6.3K citations

  2. Vanderbilt University

    Nashville, United States

    12 h-index

    99 publications

    6.6K citations

  3. Monash University

    Melbourne, Australia

    8 h-index

    27 publications

    2.3K citations

  4. University of Ferrara

    Ferrara, Italy

    7 h-index

    61 publications

    1.8K citations

  5. Inserm

    Paris, France

    5 h-index

    17 publications

    633 citations

  6. RTI International

    Durham, United States

    5 h-index

    28 publications

    748 citations

  7. United States Military Academy

    West Point, United States

    5 h-index

    46 publications

    1.6K citations

  8. University of Florida

    Gainesville, United States

    5 h-index

    6 publications

    194 citations

1–8 of 152

Venues

  1. Journal of Medicinal Chemistry

    24 publications · 1.2K citations

    20

    h-index

  2. Bioorganic & Medicinal Chemistry Letters

    18 publications · 632 citations

    18

    h-index

  3. Neuropharmacology

    11 publications · 451 citations

    11

    h-index

  4. ACS Medicinal Chemistry Letters

    6 publications · 241 citations

    6

    h-index

  5. British Journal of Pharmacology

    BJP · 5 publications · 1.3K citations

    5

    h-index

1–5