Alex B. Burgin

Resveratrol Ameliorates Aging-Related Metabolic Phenotypes by Inhibiting cAMP Phosphodiesterases

Sung Jun Park, Faiyaz Ahmad, Andrew Philp et al. · Cell · 2012 · 1.3K citations · Full text

Life Sciences, Biochemistry, Nutritional Sciences +15

The mechanism of topoisomerase I poisoning by a camptothecin analog

Bart L. Staker, Kathryn A. Hjerrild, M.D. Feese et al. · Proceedings of the National Academy of Sciences · 2002 · 802 citations · Full text

Medicine, Oncology, Pharmacology +14

Structures of Three Classes of Anticancer Agents Bound to the Human Topoisomerase I−DNA Covalent Complex

Bart L. Staker, M.D. Feese, Mark Cushman et al. · Journal of Medicinal Chemistry · 2005 · 535 citations · Full text

Life Sciences, Molecular Biology, Pharmacology +16

A eukaryotic enzyme that can disjoin dead-end covalent complexes between DNA and type I topoisomerases.

Shujun Yang, Alex B. Burgin, Beth N. Huizenga et al. · Proceedings of the National Academy of Sciences · 1996 · 405 citations

Life Sciences, Biochemistry, Molecular Biology +15

Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety

Alex B. Burgin, Ólafur Þ. Magnússon, Jasbir Singh et al. · Nature Biotechnology · 2009 · 394 citations

Pharmacy, Medicinal Chemistry, Pharmacology +12