Mark Cushman

Structures of Three Classes of Anticancer Agents Bound to the Human Topoisomerase I−DNA Covalent Complex

Bart L. Staker, M.D. Feese, Mark Cushman et al. · Journal of Medicinal Chemistry · 2005 · 535 citations · Full text

Life Sciences, Molecular Biology, Pharmacology +16

Synthesis and evaluation of stilbene and dihydrostilbene derivatives as potential anticancer agents that inhibit tubulin polymerization

Mark Cushman, Dhanapalan Nagarathnam, Dhanushya Gopal et al. · Journal of Medicinal Chemistry · 1991 · 299 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +9

Synthesis, Antitubulin and Antimitotic Activity, and Cytotoxicity of Analogs of 2-Methoxyestradiol, an Endogenous Mammalian Metabolite of Estradiol That Inhibits Tubulin Polymerization by Binding to the Colchicine Binding Site

Mark Cushman, Hu-Ming He, John A. Katzenellenbogen et al. · Journal of Medicinal Chemistry · 1995 · 186 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +16

Protein-Linked DNA Strand Breaks Induced by NSC 314622, a Novel Noncamptothecin Topoisomerase I Poison

Glenda Kohlhagen, Kenneth D. Paull, Mark Cushman et al. · Molecular Pharmacology · 1998 · 167 citations

Medicine, Oncology, Pharmacology +16

Synthesis of New Indeno[1,2-<i>c</i>]isoquinolines:  Cytotoxic Non-Camptothecin Topoisomerase I Inhibitors

Mark Cushman, Muthusamy Jayaraman, Jeffrey A. Vroman et al. · Journal of Medicinal Chemistry · 2000 · 165 citations

Pharmacy, Medicinal Chemistry, Pharmacology +11