Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety

DISC1 and PDE4B Are Interacting Genetic Factors in Schizophrenia That Regulate cAMP Signaling

J. Kirsty Millar, Ben Pickard, Shaun Mackie et al. · Science · 2005 · 651 citations

Life Sciences, Molecular Biology, Molecular Genetics +14

Phosphodiesterase 4D Deficiency in the Ryanodine-Receptor Complex Promotes Heart Failure and Arrhythmias

Stephan E. Lehnart, Xander H.T. Wehrens, Steven Reiken et al. · Cell · 2005 · 506 citations · Full text

Medicine, Biochemistry, Cardiology +14

Structural Basis for the Activity of Drugs that Inhibit Phosphodiesterases

G.L. Card, B.P. England, Yoshihisa Suzuki et al. · Structure · 2004 · 431 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +14

Phosphorylation and Activation of a cAMP-specific Phosphodiesterase by the cAMP-dependent Protein Kinase

Claudio Sette, Marco Conti · Journal of Biological Chemistry · 1996 · 409 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +13

A Family of Human Phosphodiesterases Homologous to the Dunce Learning and Memory Gene Product of <i>Drosophila melanogaster</i> are Potential Targets for Antidepressant Drugs

Graeme B. Bolger, Tamar Michaeli, Tim Martins et al. · Molecular and Cellular Biology · 1993 · 286 citations · Full text

Life Sciences, Genetics, Molecular Biology +10