DISC1 and PDE4B Are Interacting Genetic Factors in Schizophrenia That Regulate cAMP Signaling

J. Kirsty Millar, Ben Pickard, Shaun Mackie, +17

Science

Behavioral Phenotypes of Disc1 Missense Mutations in Mice

Steven J. Clapcote, Tatiana V. Lipina, J. Kirsty Millar, +15

Neuron

Knockout MouseDevelopmental BiologyGenetic DisorderGeneticsDegenerative Disease +2

Isoform-Selective Susceptibility of DISC1/Phosphodiesterase-4 Complexes to Dissociation by Elevated Intracellular cAMP Levels

Hannah Murdoch, Shaun Mackie, D.M. Collins, +5

Journal of Neuroscience

Molecular BiologyPde4c2 IsoformsCellular PhysiologyIsoform-selective SusceptibilityProtein Folding +19

DISC1 complexes with TRAK1 and Miro1 to modulate anterograde axonal mitochondrial trafficking

Fumiaki Ogawa, Elise L.V. Malavasi, Darragh Crummie, +5

Human Molecular Genetics

Molecular BiologyCytoskeletonCellular PhysiologySocial SciencesMitochondrial Disc1 +16

PKA Phosphorylation of NDE1 Is DISC1/PDE4 Dependent and Modulates Its Interaction with LIS1 and NDEL1

Nicholas J. Bradshaw, Dinesh C. Soares, Becky C. Carlyle, +7

Journal of Neuroscience

The wis1 signal transduction pathway is required for expression of cAMP-repressed genes in fission yeast

Sophie Stettler, Emma Warbrick, Simon Prochnik, +2

Journal of Cell Science

GeneticsMolecular GeneticsCell CycleCamp-repressed GenesCellular Physiology +16

The Fission Yeast Mitotic Regulator<i>win1</i>⁺Encodes an MAP Kinase Kinase Kinase That Phosphorylates and Activates Wis1 MAP Kinase Kinase in Response to High Osmolarity

Itaru Samejima, Shaun Mackie, Emma Warbrick, +2

Molecular Biology of the Cell

A t(1;11) translocation linked to schizophrenia and affective disorders gives rise to aberrant chimeric DISC1 transcripts that encode structurally altered, deleterious mitochondrial proteins

Jennifer E. Eykelenboom, Gareth James Briggs, Nicholas J. Bradshaw, +15

Human Molecular Genetics

GeneticsGenomic MechanismMolecular BiologyMolecular GeneticsEpigenetics +26

Novel brain 14‐3‐3 interacting proteins involved in neurodegenerative disease

Shaun Mackie, Alastair Aitken

FEBS Journal

DISC1 regulates N-methyl-D-aspartate receptor dynamics: abnormalities induced by a Disc1 mutation modelling a translocation linked to major mental illness

Elise L.V. Malavasi, Kyriakos D. Economides, Ellen Grünewald, +33

Translational Psychiatry

Psychiatric DisordersSynaptic TransmissionNeurotransmitterMajor Mental IllnessNeuropsychiatry +21