Timothy J. Hagen

Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety

Alex B. Burgin, Ólafur Þ. Magnússon, Jasbir Singh et al. · Nature Biotechnology · 2009 · 391 citations

Medicine, Neuropharmacology, Neuroscience +3

Synthetic and computer-assisted analyses of the pharmacophore for the benzodiazepine receptor inverse agonist site

M.S. Allen, Mark L. Trudell, Timothy J. Hagen et al. · Journal of Medicinal Chemistry · 1990 · 122 citations

Hyperglycemia and Hemorrhagic Transformation of Cerebral Infarcts

Joseph P. Broderick, Timothy J. Hagen, Thomas G. Brott et al. · Stroke · 1995 · 97 citations

Synthesis of novel 3-substituted .beta.-carbolines as benzodiazepine receptor ligands: probing the benzodiazepine receptor pharmacophore

M.S. Allen, Timothy J. Hagen, Mark L. Trudell et al. · Journal of Medicinal Chemistry · 1988 · 83 citations

Design and Synthesis of Selective Phosphodiesterase 4D (PDE4D) Allosteric Inhibitors for the Treatment of Fragile X Syndrome and Other Brain Disorders

Mark E. Gurney, Richard A. Nugent, Xuesheng Mo et al. · Journal of Medicinal Chemistry · 2019 · 73 citations · Full text

Drug Target, Earlier Pde4 Inhibitors, Lead Identification +17