Concepedia

Allosteric Modulator Design

Allosteric Modulator Design is a specialized branch of drug design that focuses on the development of compounds which bind to allosteric sites on target proteins to modulate their activity, thereby offering enhanced selectivity and fine-tuned pharmacological control compared to orthosteric agents.

738

Publications

35.8K

Citations

4.9K

Authors

892

Institutions

Publications per year

2017–2026

253

Parents

Children

Publications

738

Overcoming EGFR(T790M) and EGFR(C797S) resistance with mutant-selective allosteric inhibitors

Yong Jia, Cai‐Hong Yun, Eunyoung Park et al. · Nature · 2016 · 879 citations · Full text

, , +11

Allosteric inhibition of lysyl oxidase–like-2 impedes the development of a pathologic microenvironment

Vivian Barry-Hamilton, Rhyannon Spangler, Derek Marshall et al. · Nature Medicine · 2010 · 855 citations

, , +13

Targeting Bcr–Abl by combining allosteric with ATP-binding-site inhibitors

Jianming Zhang, Francisco Adrián, Wolfgang Jahnke et al. · Nature · 2010 · 599 citations

, , +14

The allosteric inhibitor ABL001 enables dual targeting of BCR–ABL1

Andrew A. Wylie, Joseph Schoepfer, Wolfgang Jahnke et al. · Nature · 2017 · 596 citations

, , +15

Allosteric Akt (PKB) inhibitors: discovery and SAR of isozyme selective inhibitors

Craig W. Lindsley, Zhijian Zhao, William Leister et al. · Bioorganic & Medicinal Chemistry Letters · 2004 · 501 citations · Full text

, , +14

1–5 of 738

Authors

4.9K

  1. CW
    Craig W. Lindsley

    Vanderbilt University, United States

    63 publications · 3.3K citations

    35

    h-index

  2. PJ
    P. Jeffrey Conn

    Vanderbilt University, United States

    64 publications · 2.8K citations

    35

    h-index

  3. CM
    Colleen M. Niswender

    Vanderbilt University, United States

    44 publications · 1.9K citations

    28

    h-index

  4. CK
    Carrie K. Jones

    Vanderbilt University, United States

    24 publications · 967 citations

    19

    h-index

  5. AC
    Arthur Christopoulos

    Monash University, Australia

    22 publications · 1.2K citations

    18

    h-index

1–5 of 4.9K

Institutions

892

  1. Vanderbilt University Medical Center

    Nashville, United States

    34 h-index

    391 publications

    15.7K citations

  2. Vanderbilt University

    Nashville, United States

    30 h-index

    387 publications

    16.5K citations

  3. Monash University

    Melbourne, Australia

    22 h-index

    152 publications

    6.4K citations

  4. United States Military Academy

    West Point, United States

    19 h-index

    267 publications

    17.9K citations

  5. Eli Lilly (United States)

    Indianapolis, United States

    13 h-index

    127 publications

    5.9K citations

  6. Centre National de la Recherche Scientifique

    Paris, France

    12 h-index

    61 publications

    3.6K citations

  7. University of Liège

    Liège, Belgium

    12 h-index

    72 publications

    3.6K citations

  8. Howard Hughes Medical Institute

    Chevy Chase, United States

    12 h-index

    22 publications

    3.6K citations

1–8 of 892

Venues

  1. Journal of Medicinal Chemistry

    118 publications · 6.1K citations

    47

    h-index

  2. Bioorganic & Medicinal Chemistry Letters

    123 publications · 4.4K citations

    38

    h-index

  3. Journal of Biological Chemistry

    JBC · 26 publications · 1.6K citations

    23

    h-index

  4. European Journal of Medicinal Chemistry

    29 publications · 819 citations

    19

    h-index

  5. Neuropharmacology

    20 publications · 627 citations

    17

    h-index

1–5