Concepedia

Negative Allosteric Modulators

Negative Allosteric Modulators is a type of allosteric modulator that binds to an allosteric site on a receptor protein to reduce the receptor's functional response to its primary ligand without preventing ligand binding, thereby decreasing signaling efficacy through conformational stabilization of an inactive state.

411

Publications

19.5K

Citations

2.6K

Authors

646

Institutions

Publications per year

2017–2026

164

Variants

Nams

Parents

Publications

411

Cannabidiol is a negative allosteric modulator of the cannabinoid CB <sub>1</sub> receptor

Robert B. Laprairie, Amina M. Bagher, Michael E. Kelly et al. · British Journal of Pharmacology · 2015 · 1K citations · Full text

, , +13

Psychedelics promote plasticity by directly binding to BDNF receptor TrkB

Rafael Moliner, Mykhailo Girych, Cecilia A. Brunello et al. · Nature Neuroscience · 2023 · 432 citations · Full text

, , +17

Rapid Seizure-Induced Reduction of Benzodiazepine and Zn<sup>2+</sup>Sensitivity of Hippocampal Dentate Granule Cell GABA<sub>A</sub>Receptors

Jaideep Kapur, Robert L. Macdonald · Journal of Neuroscience · 1997 · 429 citations · Full text

, , +15

The anti‐epileptic drug levetiracetam reverses the inhibition by negative allosteric modulators of neuronal GABA‐ and glycine‐gated currents

Grégory Hans, Laurent Nguyen, Véronique Rocher et al. · British Journal of Pharmacology · 2002 · 335 citations · Full text

, , +17

Allosteric and orthosteric pharmacology of cannabidiol and cannabidiol‐dimethylheptyl at the type 1 and type 2 cannabinoid receptors

Mylyne Tham, Orhan Yılmaz, Mariam Alaverdashvili et al. · British Journal of Pharmacology · 2018 · 315 citations · Full text

, , +17

1–5 of 411

Authors

2.6K

  1. PJ
    P. Jeffrey Conn

    Vanderbilt University, United States

    31 publications · 1.7K citations

    24

    h-index

  2. CW
    Craig W. Lindsley

    Vanderbilt University, United States

    27 publications · 1.4K citations

    22

    h-index

  3. CM
    Colleen M. Niswender

    Vanderbilt University, United States

    22 publications · 1.1K citations

    19

    h-index

  4. AL
    Alice L. Rodriguez

    Vanderbilt University, United States

    18 publications · 834 citations

    16

    h-index

  5. KA
    Kyle A. Emmitte

    Vanderbilt University, United States

    16 publications · 581 citations

    14

    h-index

1–5 of 2.6K

Institutions

646

  1. Vanderbilt University Medical Center

    Nashville, United States

    20 h-index

    204 publications

    11.3K citations

  2. Vanderbilt University

    Nashville, United States

    19 h-index

    163 publications

    8.2K citations

  3. Monash University

    Melbourne, Australia

    17 h-index

    110 publications

    6.2K citations

  4. Centre National de la Recherche Scientifique

    Paris, France

    16 h-index

    104 publications

    5.9K citations

  5. University of Copenhagen

    Copenhagen, Denmark

    12 h-index

    65 publications

    2.1K citations

  6. Inserm

    Paris, France

    12 h-index

    62 publications

    2.5K citations

  7. Roche (Switzerland)

    Basel, Switzerland

    11 h-index

    99 publications

    7.8K citations

  8. Discovery Institute

    Seattle, United States

    10 h-index

    24 publications

    1.3K citations

1–8 of 646

Venues

  1. Journal of Medicinal Chemistry

    30 publications · 1.4K citations

    24

    h-index

  2. Molecular Pharmacology

    24 publications · 1.4K citations

    20

    h-index

  3. Journal of Biological Chemistry

    JBC · 18 publications · 1.5K citations

    17

    h-index

  4. Bioorganic & Medicinal Chemistry Letters

    22 publications · 468 citations

    14

    h-index

  5. 13

    h-index

1–5