Concepedia

Cooperativity Modulation

Cooperativity Modulation is a biochemical mechanism-based strategy in allosteric drug design that selectively alters the magnitude and direction of cooperative interactions between ligand-binding sites within a multimeric protein complex to fine-tune receptor function.

28

Publications

1.1K

Citations

140

Authors

49

Institutions

Publications per year

2017–2026

6

Parents

Publications

28

Applying key concepts from nature: transition state stabilization, pre-concentration and cooperativity effects in dendritic biomimetics

Catherine O. Liang, Jean M. J. Fréchet · Progress in Polymer Science · 2005 · 144 citations

, , +17

Hydrogen Bonding Directed Supramolecular Polymerisation of Oligo(Phenylene‐Ethynylene)s: Cooperative Mechanism, Core Symmetry Effect and Chiral Amplification

Feng Wang, Martijn A. J. Gillissen, Patrick J. M. Stals et al. · Chemistry - A European Journal · 2012 · 85 citations · Full text

, , +11

Allosteric cross-talk in chromatin can mediate drug-drug synergy

Zenita Adhireksan, Giulia Palermo, Tina Riedel et al. · Nature Communications · 2017 · 81 citations · Full text

, , +17

Ca2+ binding to sarcoplasmic reticulum ATPase revisited. I. Mechanism of affinity and cooperativity modulation by H+ and Mg2+

Vincent Forge, Elisabeth Mintz, Florent Guillain · Journal of Biological Chemistry · 1993 · 72 citations · Full text

, , +17

Construction and characterization of a spectral probe mutant of troponin C: application to analyses of mutants with increased calcium affinity

Joyce R. Pearlstone, Thor J. Borgford, Murali Chandra et al. · Biochemistry · 1992 · 69 citations

, , +17

1–5 of 28

Authors

140

  1. BS
    Brittney S. Bates

    Vanderbilt University Medical Center, United States

    2 publications · 83 citations

    2

    h-index

  2. KA
    Kyle A. Emmitte

    Vanderbilt University, United States

    2 publications · 83 citations

    2

    h-index

  3. PJ
    P. Jeffrey Conn

    Vanderbilt University, United States

    2 publications · 83 citations

    2

    h-index

  4. KJ
    Karen J. Gregory

    Monash University, Australia

    2 publications · 83 citations

    2

    h-index

  5. SR
    Shaun R. Stauffer

    Vanderbilt University Medical Center, United States

    2 publications · 83 citations

    2

    h-index

1–5 of 140

Institutions

49

  1. Monash University

    Melbourne, Australia

    3 h-index

    36 publications

    1.4K citations

  2. National Cancer Institute

    Bethesda, United States

    2 h-index

    4 publications

    100 citations

  3. University of California, Berkeley

    Berkeley, United States

    2 h-index

    5 publications

    408 citations

  4. Vanderbilt University Medical Center

    Nashville, United States

    2 h-index

    31 publications

    1.3K citations

  5. Centre de Génétique Moléculaire

    Gif-sur-Yvette, France

    1 h-index

    3 publications

    216 citations

  6. HUN-REN Research Centre for Natural Sciences

    Budapest, Hungary

    1 h-index

    3 publications

    126 citations

  7. The Ohio State University

    Columbus, United States

    1 h-index

    7 publications

    119 citations

  8. University of Nottingham

    Nottingham, United Kingdom

    1 h-index

    3 publications

    93 citations

1–8 of 49

Venues

  1. Biochemistry

    4 publications · 168 citations

    4

    h-index

  2. Journal of Medicinal Chemistry

    3 publications · 98 citations

    3

    h-index

  3. Protein Science

    PS · 2 publications · 38 citations

    2

    h-index

  4. Inorganic Chemistry

    1 publications · 12 citations

    1

    h-index

  5. Molecular BioSystems

    1 publications · 17 citations

    1

    h-index

1–5