Concepedia

Positive Allosteric Modulators

Positive Allosteric Modulators is a class of allosteric modulators that enhance the activity of a receptor in response to a primary ligand by binding to a distinct allosteric site and inducing a conformational change that increases the receptor's functional response.

1K

Publications

50.1K

Citations

5.5K

Authors

1.1K

Institutions

Publications per year

2017–2026

377

Parents

Publications

1K

Opposite Effects of mGluR1a and mGluR5 Activation on Nucleus Accumbens Medium Spiny Neuron Dendritic Spine Density

Kellie S. Gross, Dieter D. Brandner, Luis A. Martinez et al. · PLoS ONE · 2016 · 1.6K citations · Full text

, , +17

Calcimimetics with potent and selective activity on the parathyroid calcium receptor

Edward F. Nemeth, Michael E. Steffey, Lance G. Hammerland et al. · Proceedings of the National Academy of Sciences · 1998 · 612 citations

, , +17

A Novel Positive Allosteric Modulator of the α7 Neuronal Nicotinic Acetylcholine Receptor:<i>In Vitro</i>and<i>In Vivo</i>Characterization

Raymond S Hurst, Mihály Hajós, M. Raggenbass et al. · Journal of Neuroscience · 2005 · 444 citations · Full text

, , +17

Psychedelics promote plasticity by directly binding to BDNF receptor TrkB

Rafael Moliner, Mykhailo Girych, Cecilia A. Brunello et al. · Nature Neuroscience · 2023 · 432 citations · Full text

, , +17

Rapid Seizure-Induced Reduction of Benzodiazepine and Zn<sup>2+</sup>Sensitivity of Hippocampal Dentate Granule Cell GABA<sub>A</sub>Receptors

Jaideep Kapur, Robert L. Macdonald · Journal of Neuroscience · 1997 · 429 citations · Full text

, , +15

1–5 of 1K

Authors

5.5K

  1. PJ
    P. Jeffrey Conn

    Vanderbilt University, United States

    89 publications · 5.5K citations

    45

    h-index

  2. CW
    Craig W. Lindsley

    Vanderbilt University, United States

    85 publications · 5K citations

    43

    h-index

  3. CM
    Colleen M. Niswender

    Vanderbilt University, United States

    63 publications · 3.2K citations

    36

    h-index

  4. CK
    Carrie K. Jones

    Vanderbilt University, United States

    37 publications · 2.3K citations

    28

    h-index

  5. AC
    Arthur Christopoulos

    Monash University, Australia

    37 publications · 2K citations

    25

    h-index

1–5 of 5.5K

Institutions

1.1K

  1. Vanderbilt University Medical Center

    Nashville, United States

    37 h-index

    516 publications

    29.2K citations

  2. Vanderbilt University

    Nashville, United States

    36 h-index

    566 publications

    30K citations

  3. Monash University

    Melbourne, Australia

    28 h-index

    325 publications

    16.6K citations

  4. United States Military Academy

    West Point, United States

    23 h-index

    318 publications

    19.3K citations

  5. Centre National de la Recherche Scientifique

    Paris, France

    22 h-index

    166 publications

    13K citations

  6. Janssen (Belgium)

    Beerse, Belgium

    21 h-index

    218 publications

    10.5K citations

  7. University of Copenhagen

    Copenhagen, Denmark

    18 h-index

    128 publications

    4.6K citations

  8. Inserm

    Paris, France

    17 h-index

    125 publications

    9.4K citations

1–8 of 1.1K

Venues

  1. Journal of Medicinal Chemistry

    95 publications · 4.1K citations

    42

    h-index

  2. Molecular Pharmacology

    67 publications · 5.1K citations

    39

    h-index

  3. 33

    h-index

  4. Bioorganic & Medicinal Chemistry Letters

    65 publications · 2K citations

    28

    h-index

  5. Neuropharmacology

    44 publications · 1.9K citations

    27

    h-index

1–5