Cai‐Hong Yun

The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP

Cai‐Hong Yun, Kristen E. Mengwasser, Angela V. Toms et al. · Proceedings of the National Academy of Sciences · 2008 · 2.1K citations · Full text

Medicine, Oncology, Pharmacology +14

Structures of Lung Cancer-Derived EGFR Mutants and Inhibitor Complexes: Mechanism of Activation and Insights into Differential Inhibitor Sensitivity

Cai‐Hong Yun, Titus J. Boggon, Yiqun Li et al. · Cancer Cell · 2007 · 1.2K citations · Full text

Pharmacy, Medicinal Chemistry, Oncology +15

Novel mutant-selective EGFR kinase inhibitors against EGFR T790M

Wenjun Zhou, Dalia Ercan, Liang Chen et al. · Nature · 2009 · 996 citations · Full text

Medicine, Oncology, Pharmacology +12

Overcoming EGFR(T790M) and EGFR(C797S) resistance with mutant-selective allosteric inhibitors

Yong Jia, Cai‐Hong Yun, Eunyoung Park et al. · Nature · 2016 · 879 citations · Full text

Medicine, Oncology, Pharmacology +11

Pharmacological targeting of kinases MST1 and MST2 augments tissue repair and regeneration

Fuqin Fan, Zhixiang He, Lulu Kong et al. · Science Translational Medicine · 2016 · 389 citations · Full text

Medicine, Biomedical Sciences, Medicinal Chemistry +10