Concepedia

Cai‐Hong Yun

CY

59

Publications

9.1K

Citations

39

H-Index

2004

Active since

Affiliations

Peking University(Current)

Dana-Farber Cancer Institute

Chinese Academy of Sciences

Harvard University

University of Science and Technology of China

Cai‐Hong Yun is an author at Peking University specializing in medicine, natural sciences, and drug discovery.

Top concepts

MedicineNatural SciencesMolecular BiologyPharmacologyDrug DiscoveryCell BiologyBiochemistryTumor BiologyCell SignalingSystems Biology

Publications per year

2004–2024

59

Publications

59

The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP

Cai‐Hong Yun, Kristen E. Mengwasser, Angela V. Toms et al. · Proceedings of the National Academy of Sciences · 2008 · 2.1K citations · Full text

Atp Binding Pocket, Molecular Biology, T790m Mutation +20

Structures of Lung Cancer-Derived EGFR Mutants and Inhibitor Complexes: Mechanism of Activation and Insights into Differential Inhibitor Sensitivity

Cai‐Hong Yun, Titus J. Boggon, Yiqun Li et al. · Cancer Cell · 2007 · 1.1K citations · Full text

Medicine, Inhibitor Complexes, Bronchial Neoplasm +6

Novel mutant-selective EGFR kinase inhibitors against EGFR T790M

Wenjun Zhou, Dalia Ercan, Liang Chen et al. · Nature · 2009 · 988 citations · Full text

Egfr T790m, Medicine, Receptor Tyrosine Kinase +3

Overcoming EGFR(T790M) and EGFR(C797S) resistance with mutant-selective allosteric inhibitors

Yong Jia, Cai‐Hong Yun, Eunyoung Park et al. · Nature · 2016 · 851 citations · Full text

Molecular Pharmacology, Medicine, Pharmacology +4

Pharmacological targeting of kinases MST1 and MST2 augments tissue repair and regeneration

Fuqin Fan, Zhixiang He, Lulu Kong et al. · Science Translational Medicine · 2016 · 381 citations · Full text

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