Discovery, Synthesis, And Structure-Based Optimization of a Series of <i>N</i>-(<i>tert</i>-Butyl)-2-(<i>N</i>-arylamido)-2-(pyridin-3-yl) Acetamides (ML188) as Potent Noncovalent Small Molecule Inhibitors of the Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) 3CL Protease

Jon Jacobs, Valerie Grum‐Tokars, Ya Zhou, +13

Journal of Medicinal Chemistry

Molecular DockingMedicinal ChemistryBiochemistryNih Molecular LibrariesNatural Sciences +13

Discovery of Novel Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5 Reveals Chemical and Functional Diversity and In Vivo Activity in Rat Behavioral Models of Anxiolytic and Antipsychotic Activity

Alice L. Rodriguez, Mark D. Grier, Carrie K. Jones, +17

Molecular Pharmacology

Mesoporous Encapsulated Chiral Nanogold for Use in Enantioselective Reactions

Ya Zhou, Hanjun Sun, Hongcheng Xu, +3

Angewandte Chemie International Edition

Enantioselective ReactionsEngineeringBiochemistryNatural SciencesBiocatalysis +10

Sodium Salts of Anionic Chiral Cobalt(III) Complexes as Catalysts of the Enantioselective Povarov Reaction

Jie Yu, Hua‐Jie Jiang, Ya Zhou, +2

Angewandte Chemie International Edition

Inorganic ChemistryChemical EngineeringEngineeringContiguous Stereogenic CentersAsymmetric Povarov Reaction +9

Synthesis of 5,6,7,8-Tetrahydro-1,6-naphthyridines and Related Heterocycles by Cobalt-Catalyzed [2 + 2 + 2] Cyclizations

Ya Zhou, John A. Porco, John K. Snyder

Organic Letters

A chiral covalent organic framework (COF) nanozyme with ultrahigh enzymatic activity

Ya Zhou, Wei Yue, Jinsong Ren, +1

Materials Horizons

Organic Material ChemistryUltrahigh Enzymatic ActivityBioorganic ChemistryEngineeringBiochemistry +13

Unique Signaling Profiles of Positive Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5 Determine Differences in In Vivo Activity

Jerri M. Rook, Meredith J. Noetzel, Wendy A. Pouliot, +15

Biological Psychiatry

Signal TransductionFunctional SelectivityMedicinePositive Allosteric ModulatorsNeurotransmitter +7

How functional groups influence the ROS generation and cytotoxicity of graphene quantum dots

Ya Zhou, Hanjun Sun, Faming Wang, +2

Chemical Communications

Phenol-like group functionalized graphene quantum dots structurally mimicking natural antioxidants for highly efficient acute kidney injury treatment

Huan Wang, Dongqin Yu, Fang Jiao, +5

Chemical Science

Investigating Metabotropic Glutamate Receptor 5 Allosteric Modulator Cooperativity, Affinity, and Agonism: Enriching Structure-Function Studies and Structure-Activity Relationships

Karen J. Gregory, Meredith J. Noetzel, Jerri M. Rook, +11

Molecular Pharmacology