Jon Jacobs

Discovery, Synthesis, And Structure-Based Optimization of a Series of <i>N</i>-(<i>tert</i>-Butyl)-2-(<i>N</i>-arylamido)-2-(pyridin-3-yl) Acetamides (ML188) as Potent Noncovalent Small Molecule Inhibitors of the Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) 3CL Protease

Jon Jacobs, Valerie Grum‐Tokars, Ya Zhou et al. · Journal of Medicinal Chemistry · 2012 · 202 citations · Full text

Molecular Docking, Medicinal Chemistry, Biochemistry +15

Discovery of N-(benzo[1,2,3]triazol-1-yl)-N-(benzyl)acetamido)phenyl) carboxamides as severe acute respiratory syndrome coronavirus (SARS-CoV) 3CLpro inhibitors: Identification of ML300 and noncovalent nanomolar inhibitors with an induced-fit binding

Mark Turlington, Aspen Chun, Sakshi Tomar et al. · Bioorganic & Medicinal Chemistry Letters · 2013 · 129 citations · Full text

Noncovalent Nanomolar Inhibitors, Medicine, Antiviral Therapy +6

Tetrahydronaphthyridine and Dihydronaphthyridinone Ethers As Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 5 (mGlu₅)

Mark Turlington, Chrysa Malosh, Jon Jacobs et al. · Journal of Medicinal Chemistry · 2014 · 13 citations · Full text

Selective Mglu5 Pam, Drug Target, Dihydronaphthyridinone Ethers +19