Sakshi Tomar

Discovery, Synthesis, And Structure-Based Optimization of a Series of <i>N</i>-(<i>tert</i>-Butyl)-2-(<i>N</i>-arylamido)-2-(pyridin-3-yl) Acetamides (ML188) as Potent Noncovalent Small Molecule Inhibitors of the Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) 3CL Protease

Jon Jacobs, Valerie Grum‐Tokars, Ya Zhou et al. · Journal of Medicinal Chemistry · 2012 · 202 citations · Full text

Molecular Docking, Medicinal Chemistry, Biochemistry +15

Ligand-induced Dimerization of Middle East Respiratory Syndrome (MERS) Coronavirus nsp5 Protease (3CLpro)

Sakshi Tomar, Melanie L. Johnston, Sarah E. St. John et al. · Journal of Biological Chemistry · 2015 · 171 citations · Full text

Protease Inhibitors, Virus Structure, Coronavirus Nsp5 Protease +8

Discovery of N-(benzo[1,2,3]triazol-1-yl)-N-(benzyl)acetamido)phenyl) carboxamides as severe acute respiratory syndrome coronavirus (SARS-CoV) 3CLpro inhibitors: Identification of ML300 and noncovalent nanomolar inhibitors with an induced-fit binding

Mark Turlington, Aspen Chun, Sakshi Tomar et al. · Bioorganic & Medicinal Chemistry Letters · 2013 · 129 citations · Full text

Noncovalent Nanomolar Inhibitors, Medicine, Antiviral Therapy +6

Chimeric Exchange of Coronavirus nsp5 Proteases (3CLpro) Identifies Common and Divergent Regulatory Determinants of Protease Activity

Christopher C. Stobart, Nicole R. Sexton, Havisha Munjal et al. · Journal of Virology · 2013 · 127 citations · Full text

Viral Replication, Viral Pathogenesis, Molecular Biology +19

Targeting zoonotic viruses: Structure-based inhibition of the 3C-like protease from bat coronavirus HKU4—The likely reservoir host to the human coronavirus that causes Middle East Respiratory Syndrome (MERS)

Sarah E. St. John, Sakshi Tomar, Shaun R. Stauffer et al. · Bioorganic & Medicinal Chemistry · 2015 · 97 citations · Full text

Protease Inhibitors, 3C-like Protease, Virus Structure +10