Sarah E. St. John

Ligand-induced Dimerization of Middle East Respiratory Syndrome (MERS) Coronavirus nsp5 Protease (3CLpro)

Sakshi Tomar, Melanie L. Johnston, Sarah E. St. John et al. · Journal of Biological Chemistry · 2015 · 176 citations · Full text

Life Sciences, Infectious Diseases, Molecular Biology +16

Coronaviruses Resistant to a 3C-Like Protease Inhibitor Are Attenuated for Replication and Pathogenesis, Revealing a Low Genetic Barrier but High Fitness Cost of Resistance

Xufang Deng, Sarah E. St. John, Heather L. Osswald et al. · Journal of Virology · 2014 · 103 citations · Full text

Life Sciences, Infectious Diseases, Molecular Genetics +17

Targeting zoonotic viruses: Structure-based inhibition of the 3C-like protease from bat coronavirus HKU4—The likely reservoir host to the human coronavirus that causes Middle East Respiratory Syndrome (MERS)

Sarah E. St. John, Sakshi Tomar, Shaun R. Stauffer et al. · Bioorganic & Medicinal Chemistry · 2015 · 97 citations · Full text

Life Sciences, Biology, Infectious Diseases +17

Design, synthesis, biological and structural evaluation of functionalized resveratrol analogues as inhibitors of quinone reductase 2

Sarah E. St. John, Katherine C. Jensen, Soosung Kang et al. · Bioorganic & Medicinal Chemistry · 2013 · 28 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +11

X-ray structure and inhibition of the feline infectious peritonitis virus 3C-like protease: Structural implications for drug design

Sarah E. St. John, Matthew D. Therkelsen, Prasanth R. Nyalapatla et al. · Bioorganic & Medicinal Chemistry Letters · 2015 · 26 citations · Full text

Life Sciences, Biochemistry, Infectious Diseases +16