Heather L. Osswald

Ligand-induced Dimerization of Middle East Respiratory Syndrome (MERS) Coronavirus nsp5 Protease (3CLpro)

Sakshi Tomar, Melanie L. Johnston, Sarah E. St. John et al. · Journal of Biological Chemistry · 2015 · 171 citations · Full text

Protease Inhibitors, Virus Structure, Coronavirus Nsp5 Protease +8

Coronaviruses Resistant to a 3C-Like Protease Inhibitor Are Attenuated for Replication and Pathogenesis, Revealing a Low Genetic Barrier but High Fitness Cost of Resistance

Xufang Deng, Sarah E. St. John, Heather L. Osswald et al. · Journal of Virology · 2014 · 102 citations · Full text

Design and Development of Highly Potent HIV-1 Protease Inhibitors with a Crown-Like Oxotricyclic Core as the P2-Ligand To Combat Multidrug-Resistant HIV Variants

Arun K. Ghosh, Kalapala Venkateswara Rao, Prasanth R. Nyalapatla et al. · Journal of Medicinal Chemistry · 2017 · 73 citations · Full text

Combinatorial Chemistry, Medicinal Chemistry, Hiv-1 Protease +15

A Mouse Model for <i>Betacoronavirus</i> Subgroup 2c Using a Bat Coronavirus Strain HKU5 Variant

Sudhakar Agnihothram, Boyd L. Yount, Eric Donaldson et al. · mBio · 2014 · 60 citations · Full text

Modular, stereocontrolled C _β –H/C _α –C activation of alkyl carboxylic acids

Ming Shang, Karla Santos Feu, Julien C. Vantourout et al. · Proceedings of the National Academy of Sciences · 2019 · 52 citations · Full text