Heather L. Osswald

Ligand-induced Dimerization of Middle East Respiratory Syndrome (MERS) Coronavirus nsp5 Protease (3CLpro)

Sakshi Tomar, Melanie L. Johnston, Sarah E. St. John et al. · Journal of Biological Chemistry · 2015 · 176 citations · Full text

Life Sciences, Infectious Diseases, Molecular Biology +16

Coronaviruses Resistant to a 3C-Like Protease Inhibitor Are Attenuated for Replication and Pathogenesis, Revealing a Low Genetic Barrier but High Fitness Cost of Resistance

Xufang Deng, Sarah E. St. John, Heather L. Osswald et al. · Journal of Virology · 2014 · 103 citations · Full text

Life Sciences, Infectious Diseases, Molecular Genetics +17

Design and Development of Highly Potent HIV-1 Protease Inhibitors with a Crown-Like Oxotricyclic Core as the P2-Ligand To Combat Multidrug-Resistant HIV Variants

Arun K. Ghosh, Kalapala Venkateswara Rao, Prasanth R. Nyalapatla et al. · Journal of Medicinal Chemistry · 2017 · 73 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

A Mouse Model for <i>Betacoronavirus</i> Subgroup 2c Using a Bat Coronavirus Strain HKU5 Variant

Sudhakar Agnihothram, Boyd L. Yount, Eric Donaldson et al. · mBio · 2014 · 60 citations · Full text

Life Sciences, Infectious Diseases, Molecular Virology +16

A novel central nervous system-penetrating protease inhibitor overcomes human immunodeficiency virus 1 resistance with unprecedented aM to pM potency

Manabu Aoki, Hironori Hayashi, Kalapala Venkateswara Rao et al. · eLife · 2017 · 53 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17