Manabu Aoki

Novel Low Molecular Weight Spirodiketopiperazine Derivatives Potently Inhibit R5 HIV-1 Infection through Their Antagonistic Effects on CCR5

Kenji Maeda, Kazuhisa Yoshimura, Shiro Shibayama et al. · Journal of Biological Chemistry · 2001 · 126 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +8

Missense mutation of the interleukin-12 receptor β1 chain–encoding gene is associated with impaired immunity againstMycobacterium avium complex infection

Tatsunori Sakai, Masao Matsuoka, Manabu Aoki et al. · Blood · 2001 · 88 citations · Full text

Life Sciences, Immunology, Microbiology +14

Single atom changes in newly synthesized HIV protease inhibitors reveal structural basis for extreme affinity, high genetic barrier, and adaptation to the HIV protease plasticity

Haydar Bulut, Shin‐ichiro Hattori, Hiromi Aoki-Ogata et al. · Scientific Reports · 2020 · 82 citations · Full text

Life Sciences, Medicinal Chemistry, Molecular Biology +16

Dimerization of HIV-1 protease occurs through two steps relating to the mechanism of protease dimerization inhibition by darunavir

Hironori Hayashi, Nobutoki Takamune, Takashi Nirasawa et al. · Proceedings of the National Academy of Sciences · 2014 · 78 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Design and Development of Highly Potent HIV-1 Protease Inhibitors with a Crown-Like Oxotricyclic Core as the P2-Ligand To Combat Multidrug-Resistant HIV Variants

Arun K. Ghosh, Kalapala Venkateswara Rao, Prasanth R. Nyalapatla et al. · Journal of Medicinal Chemistry · 2017 · 73 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17