Hiromi Aoki-Ogata

Single atom changes in newly synthesized HIV protease inhibitors reveal structural basis for extreme affinity, high genetic barrier, and adaptation to the HIV protease plasticity

Haydar Bulut, Shin‐ichiro Hattori, Hiromi Aoki-Ogata et al. · Scientific Reports · 2020 · 82 citations · Full text

Life Sciences, Medicinal Chemistry, Molecular Biology +16

A novel central nervous system-penetrating protease inhibitor overcomes human immunodeficiency virus 1 resistance with unprecedented aM to pM potency

Manabu Aoki, Hironori Hayashi, Kalapala Venkateswara Rao et al. · eLife · 2017 · 53 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Mechanism of Darunavir (DRV)’s High Genetic Barrier to HIV-1 Resistance: A Key V32I Substitution in Protease Rarely Occurs, but Once It Occurs, It Predisposes HIV-1 To Develop DRV Resistance

Manabu Aoki, Debananda Das, Hironori Hayashi et al. · mBio · 2018 · 53 citations · Full text

Life Sciences, Genetics, Infectious Diseases +17

Loss of Protease Dimerization Inhibition Activity of Darunavir Is Associated with the Acquisition of Resistance to Darunavir by HIV-1

Yasuhiro Koh, Manabu Aoki, Matthew Danish et al. · Journal of Virology · 2011 · 44 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Non-Cleavage Site Gag Mutations in Amprenavir-Resistant Human Immunodeficiency Virus Type 1 (HIV-1) Predispose HIV-1 to Rapid Acquisition of Amprenavir Resistance but Delay Development of Resistance to Other Protease Inhibitors

Manabu Aoki, David Venzon, Yasuhiro Koh et al. · Journal of Virology · 2009 · 28 citations · Full text

Life Sciences, Infectious Diseases, Molecular Biology +17