Concepedia

Hiromi Aoki-Ogata

HA

Statistics

Publications

8

Citations

315

H-Index

8

Active since

2009

Affiliations

National Institutes of Health(Current)

National Cancer Institute

Kumamoto University

Kumamoto Health Science University

Purdue University West Lafayette

Hiromi Aoki-Ogata is an author at National Institutes of Health specializing in pharmacology, drug resistance, and medicine.

Top concepts

Publications per year

2009–2020

8

Publications

8

Single atom changes in newly synthesized HIV protease inhibitors reveal structural basis for extreme affinity, high genetic barrier, and adaptation to the HIV protease plasticity

Haydar Bulut, Shin‐ichiro Hattori, Hiromi Aoki-Ogata et al. · Scientific Reports · 2020 · 81 citations · Full text

Mechanism of Darunavir (DRV)’s High Genetic Barrier to HIV-1 Resistance: A Key V32I Substitution in Protease Rarely Occurs, but Once It Occurs, It Predisposes HIV-1 To Develop DRV Resistance

Manabu Aoki, Debananda Das, Hironori Hayashi et al. · mBio · 2018 · 52 citations · Full text

A novel central nervous system-penetrating protease inhibitor overcomes human immunodeficiency virus 1 resistance with unprecedented aM to pM potency

Manabu Aoki, Hironori Hayashi, Kalapala Venkateswara Rao et al. · eLife · 2017 · 51 citations · Full text

Loss of Protease Dimerization Inhibition Activity of Darunavir Is Associated with the Acquisition of Resistance to Darunavir by HIV-1

Yasuhiro Koh, Manabu Aoki, Matthew Danish et al. · Journal of Virology · 2011 · 43 citations · Full text

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Non-Cleavage Site Gag Mutations in Amprenavir-Resistant Human Immunodeficiency Virus Type 1 (HIV-1) Predispose HIV-1 to Rapid Acquisition of Amprenavir Resistance but Delay Development of Resistance to Other Protease Inhibitors

Manabu Aoki, David Venzon, Yasuhiro Koh et al. · Journal of Virology · 2009 · 28 citations · Full text

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