Discovery, Characterization, and Antiparkinsonian Effect of Novel Positive Allosteric Modulators of Metabotropic Glutamate Receptor 4

Colleen M. Niswender, Kari A. Johnson, C. David Weaver, +15

Molecular Pharmacology

Discovery of Novel Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5 Reveals Chemical and Functional Diversity and In Vivo Activity in Rat Behavioral Models of Anxiolytic and Antipsychotic Activity

Alice L. Rodriguez, Mark D. Grier, Carrie K. Jones, +17

Molecular Pharmacology

ML297 (VU0456810), the First Potent and Selective Activator of the GIRK Potassium Channel, Displays Antiepileptic Properties in Mice

Kristian Kaufmann, Ian M. Romaine, Emily Days, +14

ACS Chemical Neuroscience

Discovery and Characterization of Novel Allosteric Potentiators of M1 Muscarinic Receptors Reveals Multiple Modes of Activity

Joy E. Marlo, Colleen M. Niswender, Emily Days, +16

Molecular Pharmacology

Small-molecule screen identifies inhibitors of the neuronal K-Cl cotransporter KCC2

Eric Delpire, Emily Days, L. Michelle Lewis, +4

Proceedings of the National Academy of Sciences

Functional Impact of Allosteric Agonist Activity of Selective Positive Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5 in Regulating Central Nervous System Function

Meredith J. Noetzel, Jerri M. Rook, Paige N. Vinson, +13

Molecular Pharmacology

An insecticide resistance-breaking mosquitocide targeting inward rectifier potassium channels in vectors of Zika virus and malaria

Daniel R. Swale, Darren W. Engers, Sean R. Bollinger, +10

Scientific Reports

Discovery and optimization of a novel, selective and brain penetrant M1 positive allosteric modulator (PAM): The development of ML169, an MLPCN probe

Paul R. Reid, Thomas M. Bridges, Douglas J. Sheffler, +10

Bioorganic & Medicinal Chemistry Letters

Drug DiscoveryMolecular BiologyPeptide ScienceMlpcn ProbeMedicine +2

Identification of Positive Allosteric Modulators VU0155094 (ML397) and VU0422288 (ML396) Reveals New Insights into the Biology of Metabotropic Glutamate Receptor 7

Nidhi Jalan‐Sakrikar, Julie R. Field, Rebecca Klar, +20

ACS Chemical Neuroscience

Molecular BiologyNew InsightsMglu7 ActivitySocial SciencesDifferential Activity +15

Discovery, Characterization, and Effects on Renal Fluid and Electrolyte Excretion of the Kir4.1 Potassium Channel Pore Blocker, VU0134992

Sujay V. Kharade, H. Kurata, Aaron M. Bender, +13

Molecular Pharmacology