Kiran K. Gogi

Development of a novel, CNS-penetrant, metabotropic glutamate receptor 3 (mGlu3) NAM probe (ML289) derived from a closely related mGlu5 PAM

Douglas J. Sheffler, Cody J. Wenthur, Joshua Andrew Bruner et al. · Bioorganic & Medicinal Chemistry Letters · 2012 · 40 citations · Full text

Life Sciences, Neurobiology, Neuroscience +13

Exploration of Allosteric Agonism Structure–Activity Relationships within an Acetylene Series of Metabotropic Glutamate Receptor 5 (mGlu₅) Positive Allosteric Modulators (PAMs): Discovery of 5-((3-Fluorophenyl)ethynyl)-<i>N</i>-(3-methyloxetan-3-yl)picolinamide (ML254)

Mark Turlington, Meredith J. Noetzel, Aspen Chun et al. · Journal of Medicinal Chemistry · 2013 · 28 citations · Full text

Medicine, Neuroscience, Pharmacology +17

Dihydrothiazolopyridone Derivatives as a Novel Family of Positive Allosteric Modulators of the Metabotropic Glutamate 5 (mGlu₅) Receptor

José Manuel Bartolomé-Nebreda, Susana Conde-Ceide, Francisca Delgado et al. · Journal of Medicinal Chemistry · 2013 · 23 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17

Optimization of an ether series of mGlu5 positive allosteric modulators: Molecular determinants of MPEP-site interaction crossover

Jason Manka, Paige N. Vinson, Karen J. Gregory et al. · Bioorganic & Medicinal Chemistry Letters · 2012 · 12 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14