Concepedia

Allosteric Modulator Binding

Allosteric Modulator Binding is a biochemical interaction process in which a regulatory molecule binds to a site distinct from the enzyme's active site, thereby inducing a conformational change that modulates the enzyme's functional activity.

597

Publications

29.2K

Citations

4K

Authors

935

Institutions

Publications per year

2017–2026

231

Parents

Publications

597

Pregnenolone sulfate: a positive allosteric modulator at the N-methyl-D-aspartate receptor.

Fong‐Sen Wu, Terrell T. Gibbs, David H. Farb · Molecular Pharmacology · 1991 · 530 citations

, , +17

A Novel Positive Allosteric Modulator of the α7 Neuronal Nicotinic Acetylcholine Receptor:<i>In Vitro</i>and<i>In Vivo</i>Characterization

Raymond S Hurst, Mihály Hajós, M. Raggenbass et al. · Journal of Neuroscience · 2005 · 444 citations · Full text

, , +17

Cannabidiol is an allosteric modulator at mu- and delta-opioid receptors

M. Kathmann, Karsten Flau, Agnes Redmer et al. · Naunyn-Schmiedeberg s Archives of Pharmacology · 2006 · 373 citations

, , +13

Allosteric and orthosteric pharmacology of cannabidiol and cannabidiol‐dimethylheptyl at the type 1 and type 2 cannabinoid receptors

Mylyne Tham, Orhan Yılmaz, Mariam Alaverdashvili et al. · British Journal of Pharmacology · 2018 · 315 citations · Full text

, , +17

A Novel Selective Positive Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5 Has in Vivo Activity and Antipsychotic-Like Effects in Rat Behavioral Models

Gene G. Kinney, Julie A. O’Brien, Wei Lemaire et al. · Journal of Pharmacology and Experimental Therapeutics · 2005 · 299 citations

, , +17

1–5 of 597

Authors

4K

  1. PJ
    P. Jeffrey Conn

    Vanderbilt University, United States

    34 publications · 2.4K citations

    29

    h-index

  2. CW
    Craig W. Lindsley

    Vanderbilt University, United States

    30 publications · 2.1K citations

    25

    h-index

  3. AC
    Arthur Christopoulos

    Monash University, Australia

    29 publications · 1.7K citations

    24

    h-index

  4. CM
    Colleen M. Niswender

    Vanderbilt University, United States

    18 publications · 746 citations

    17

    h-index

  5. PM
    Patrick M. Sexton

    Monash University, Australia

    16 publications · 1.2K citations

    15

    h-index

1–5 of 4K

Institutions

935

  1. Monash University

    Melbourne, Australia

    24 h-index

    229 publications

    11.9K citations

  2. Vanderbilt University Medical Center

    Nashville, United States

    23 h-index

    213 publications

    11.6K citations

  3. Vanderbilt University

    Nashville, United States

    22 h-index

    157 publications

    7.1K citations

  4. Centre National de la Recherche Scientifique

    Paris, France

    19 h-index

    132 publications

    7.9K citations

  5. National Institutes of Health

    Bethesda, United States

    17 h-index

    79 publications

    4K citations

  6. Inserm

    Paris, France

    15 h-index

    82 publications

    3.8K citations

  7. University of Copenhagen

    Copenhagen, Denmark

    14 h-index

    86 publications

    3.2K citations

  8. Discovery Institute

    Seattle, United States

    13 h-index

    50 publications

    2.6K citations

1–8 of 935

Venues

  1. Journal of Medicinal Chemistry

    40 publications · 2.2K citations

    31

    h-index

  2. Molecular Pharmacology

    41 publications · 2.9K citations

    30

    h-index

  3. 25

    h-index

  4. Neuropharmacology

    30 publications · 1.4K citations

    22

    h-index

  5. Journal of Biological Chemistry

    JBC · 24 publications · 1.5K citations

    22

    h-index

1–5