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Discovery and characterization of N-(1,3-dialkyl-1H-indazol-6-yl)-1H-pyrazolo[4,3-b]pyridin-3-amine scaffold as mGlu4 positive allosteric modulators that mitigate CYP1A2 induction liability

Darren W. Engers, Sean R. Bollinger, Julie L. Engers, Joseph D. Panarese, Megan M. Breiner, Alison R. Gregro, Anna L. Blobaum, Joanne J. Bronson, Yong‐Jin Wu, John E. Macor,

Bioorganic & Medicinal Chemistry Letters · 2018 · 14 citations · 12 references

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12

Circuits and Circuit Disorders of the Basal Ganglia

Mahlon R. DeLong, Thomas Wichmann · Archives of Neurology · 2007 · 1.1K citations

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Allosteric modulation of group III metabotropic glutamate receptor 4: A potential approach to Parkinson's disease treatment

Michael J. Marino, David L. Williams, Julie A. O’Brien et al. · Proceedings of the National Academy of Sciences · 2003 · 237 citations · Full text

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Group III Metabotropic Glutamate Receptor-Mediated Modulation of the Striatopallidal Synapse

Ornella Valenti, Michael J. Marino, Marion Wittmann et al. · Journal of Neuroscience · 2003 · 161 citations · Full text

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The Metabotropic Glutamate Receptor 4-Positive Allosteric Modulator VU0364770 Produces Efficacy Alone and in Combination with l-DOPA or an Adenosine 2A Antagonist in Preclinical Rodent Models of Parkinson’s Disease

Carrie K. Jones, Michael Bubser, Analisa D. Thompson et al. · Journal of Pharmacology and Experimental Therapeutics · 2011 · 100 citations

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Synthesis and Evaluation of a Series of Heterobiarylamides That Are Centrally Penetrant Metabotropic Glutamate Receptor 4 (mGluR4) Positive Allosteric Modulators (PAMs)

Darren W. Engers, Colleen M. Niswender, C. David Weaver et al. · Journal of Medicinal Chemistry · 2009 · 81 citations · Full text

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