Centrally Active Allosteric Potentiators of the M4 Muscarinic Acetylcholine Receptor Reverse Amphetamine-Induced Hyperlocomotor Activity in Rats

Ashley E. Brady, Carrie K. Jones, Thomas M. Bridges, +10

Journal of Pharmacology and Experimental Therapeutics

Discovery, Characterization, and Antiparkinsonian Effect of Novel Positive Allosteric Modulators of Metabotropic Glutamate Receptor 4

Colleen M. Niswender, Kari A. Johnson, C. David Weaver, +15

Molecular Pharmacology

Biased mGlu 5 -Positive Allosteric Modulators Provide In Vivo Efficacy without Potentiating mGlu 5 Modulation of NMDAR Currents

Jerri M. Rook, Zixiu Xiang, Xiaohui Lv, +27

Neuron

Signal TransductionMolecular PhysiologyMglu 5Neuromodulation (Medicine)Medicine +7

Antipsychotic Drug-Like Effects of the Selective M4 Muscarinic Acetylcholine Receptor Positive Allosteric Modulator VU0152100

Nellie Byun, Michael Grannan, Michael Bubser, +18

Neuropsychopharmacology

PsychiatryFunctional SelectivityMedicinePsychopharmacologySchizophrenia +7

The Metabotropic Glutamate Receptor 4-Positive Allosteric Modulator VU0364770 Produces Efficacy Alone and in Combination with l-DOPA or an Adenosine 2A Antagonist in Preclinical Rodent Models of Parkinson’s Disease

Carrie K. Jones, Michael Bubser, Analisa D. Thompson, +15

Journal of Pharmacology and Experimental Therapeutics

The Discovery and Characterization of ML218: A Novel, Centrally Active T-Type Calcium Channel Inhibitor with Robust Effects in STN Neurons and in a Rodent Model of Parkinson’s Disease

Zixiu Xiang, Analisa D. Thompson, John T. Brogan, +22

ACS Chemical Neuroscience

Roles of the M1 Muscarinic Acetylcholine Receptor Subtype in the Regulation of Basal Ganglia Function and Implications for the Treatment of Parkinson’s Disease

Zixiu Xiang, Analisa D. Thompson, Carrie K. Jones, +2

Journal of Pharmacology and Experimental Therapeutics

Discovery of a Selective and CNS Penetrant Negative Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 3 with Antidepressant and Anxiolytic Activity in Rodents

Julie L. Engers, Alice L. Rodriguez, Leah C. Konkol, +13

Journal of Medicinal Chemistry

Therapeutic PotentialNeurotransmitterImmunologyPharmacotherapyExperimental Pharmacology +18

Discovery, Synthesis, and Structure–Activity Relationship Development of a Series of <i>N</i>-4-(2,5-Dioxopyrrolidin-1-yl)phenylpicolinamides (VU0400195, ML182): Characterization of a Novel Positive Allosteric Modulator of the Metabotropic Glutamate Receptor 4 (mGlu₄) with Oral Efficacy in an Antiparkinsonian Animal Model

Carrie K. Jones, Darren W. Engers, Analisa D. Thompson, +15

Journal of Medicinal Chemistry

Antiparkinsonian Animal ModelBrain ExposureWell-established Antiparkinsonian ModelPeptide SciencePharmacotherapy +18

Sex-specificity and estrogen-dependence of kappa opioid receptor-mediated antinociception and antihyperalgesia

Kera P. Lawson, Subodh Nag, Analisa D. Thompson, +1

Pain

Hormonal ContraceptiveHealth SciencesPain MedicineMedicinePhysiology +12