Jerri M. Rook

Discovery of Novel Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5 Reveals Chemical and Functional Diversity and In Vivo Activity in Rat Behavioral Models of Anxiolytic and Antipsychotic Activity

Alice L. Rodriguez, Mark D. Grier, Carrie K. Jones et al. · Molecular Pharmacology · 2010 · 179 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17

Biased mGlu 5 -Positive Allosteric Modulators Provide In Vivo Efficacy without Potentiating mGlu 5 Modulation of NMDAR Currents

Jerri M. Rook, Zixiu Xiang, Xiaohui Lv et al. · Neuron · 2015 · 129 citations · Full text

Life Sciences, Neuroscience, Pharmacology +16

Functional Impact of Allosteric Agonist Activity of Selective Positive Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5 in Regulating Central Nervous System Function

Meredith J. Noetzel, Jerri M. Rook, Paige N. Vinson et al. · Molecular Pharmacology · 2011 · 127 citations · Full text

Life Sciences, Neuroscience, Pharmacology +17

Potentiation of M1 Muscarinic Receptor Reverses Plasticity Deficits and Negative and Cognitive Symptoms in a Schizophrenia Mouse Model

Ayan Ghoshal, Jerri M. Rook, Jonathan W. Dickerson et al. · Neuropsychopharmacology · 2015 · 107 citations · Full text

Life Sciences, Neuroscience, Pharmacology +14

Unique Signaling Profiles of Positive Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5 Determine Differences in In Vivo Activity

Jerri M. Rook, Meredith J. Noetzel, Wendy A. Pouliot et al. · Biological Psychiatry · 2012 · 106 citations · Full text

Life Sciences, Neuroscience, Pharmacology +17