Megan M. Breiner

Design and Synthesis of <i>N</i>-Aryl Phenoxyethoxy Pyridinones as Highly Selective and CNS Penetrant mGlu₃ NAMs

Julie L. Engers, Katrina A. Bollinger, Rebecca L. Weiner et al. · ACS Medicinal Chemistry Letters · 2017 · 44 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14

Discovery of Novel Central Nervous System Penetrant Metabotropic Glutamate Receptor Subtype 2 (mGlu ₂ ) Negative Allosteric Modulators (NAMs) Based on Functionalized Pyrazolo[1,5- <i>a</i> ]pyrimidine-5-carboxamide and Thieno[3,2- <i>b</i> ]pyridine-5-carboxamide Cores

Elizabeth S. Childress, Joshua M. Wieting, Andrew S. Felts et al. · Journal of Medicinal Chemistry · 2018 · 24 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15

Discovery and characterization of N-(1,3-dialkyl-1H-indazol-6-yl)-1H-pyrazolo[4,3-b]pyridin-3-amine scaffold as mGlu4 positive allosteric modulators that mitigate CYP1A2 induction liability

Darren W. Engers, Sean R. Bollinger, Julie L. Engers et al. · Bioorganic & Medicinal Chemistry Letters · 2018 · 14 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14