Julie L. Engers

mGlu2 and mGlu3 Negative Allosteric Modulators Divergently Enhance Thalamocortical Transmission and Exert Rapid Antidepressant-like Effects

Max E. Joffe, Chiaki I. Santiago, Kendra H. Oliver et al. · Neuron · 2019 · 75 citations · Full text

Neuromodulation (Medicine), Psychiatry, Neurophysiology +8

Discovery of a Selective and CNS Penetrant Negative Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 3 with Antidepressant and Anxiolytic Activity in Rodents

Julie L. Engers, Alice L. Rodriguez, Leah C. Konkol et al. · Journal of Medicinal Chemistry · 2015 · 67 citations · Full text

Therapeutic Potential, Neurotransmitter, Immunology +20

Mechanisms underlying prelimbic prefrontal cortex mGlu3/mGlu5-dependent plasticity and reversal learning deficits following acute stress

Max E. Joffe, Chiaki I. Santiago, Branden J. Stansley et al. · Neuropharmacology · 2018 · 58 citations

Synaptic Plasticity, Neuropsychology, Stress Hormone +14

Diverse Effects on M₁ Signaling and Adverse Effect Liability within a Series of M₁ Ago-PAMs

Jerri M. Rook, Masahito Abe, Hyekyung P. Cho et al. · ACS Chemical Neuroscience · 2016 · 56 citations

Discovery of (<i>R</i>)-(2-Fluoro-4-((-4-methoxyphenyl)ethynyl)phenyl) (3-Hydroxypiperidin-1-yl)methanone (ML337), An mGlu₃ Selective and CNS Penetrant Negative Allosteric Modulator (NAM)

Cody J. Wenthur, Ryan D. Morrison, Andrew S. Felts et al. · Journal of Medicinal Chemistry · 2013 · 55 citations · Full text

Chemical Biology, Pharmaceutical Chemistry, Translational Pharmacology +17