Darren W. Engers

The Metabotropic Glutamate Receptor 4-Positive Allosteric Modulator VU0364770 Produces Efficacy Alone and in Combination with l-DOPA or an Adenosine 2A Antagonist in Preclinical Rodent Models of Parkinson’s Disease

Carrie K. Jones, Michael Bubser, Analisa D. Thompson et al. · Journal of Pharmacology and Experimental Therapeutics · 2011 · 100 citations

Medicine, Neuroscience, Pharmacology +17

Selective Inhibition of the K_ir2 Family of Inward Rectifier Potassium Channels by a Small Molecule Probe: The Discovery, SAR, and Pharmacological Characterization of ML133

Hao‐ran Wang, Meng Wu, Haibo Yu et al. · ACS Chemical Biology · 2011 · 99 citations

Medicine, Medicinal Chemistry, Pharmacology +17

Synthesis and structure–activity relationships of a novel and selective bone morphogenetic protein receptor (BMP) inhibitor derived from the pyrazolo[1.5-a]pyrimidine scaffold of Dorsomorphin: The discovery of ML347 as an ALK2 versus ALK3 selective MLPCN probe

Darren W. Engers, Audrey Y. Frist, Craig W. Lindsley et al. · Bioorganic & Medicinal Chemistry Letters · 2013 · 81 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14

Synthesis and Evaluation of a Series of Heterobiarylamides That Are Centrally Penetrant Metabotropic Glutamate Receptor 4 (mGluR4) Positive Allosteric Modulators (PAMs)

Darren W. Engers, Colleen M. Niswender, C. David Weaver et al. · Journal of Medicinal Chemistry · 2009 · 81 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17

M1-positive allosteric modulators lacking agonist activity provide the optimal profile for enhancing cognition

Sean P. Moran, Jonathan W. Dickerson, Hyekyung P. Cho et al. · Neuropsychopharmacology · 2018 · 81 citations

Life Sciences, Neuroscience, Pharmacology +15