The Discovery and Characterization of ML218: A Novel, Centrally Active T-Type Calcium Channel Inhibitor with Robust Effects in STN Neurons and in a Rodent Model of Parkinson’s Disease

Zixiu Xiang, Analisa D. Thompson, John T. Brogan, +22

ACS Chemical Neuroscience

Selective Inhibition of the K_ir2 Family of Inward Rectifier Potassium Channels by a Small Molecule Probe: The Discovery, SAR, and Pharmacological Characterization of ML133

Hao‐ran Wang, Meng Wu, Haibo Yu, +10

ACS Chemical Biology

Pharmacological CharacterizationMolecular BiologyCellular PhysiologyMolecular PharmacologyHyperpolarization (Biology) +20

Dynamic subunit stoichiometry confers a progressive continuum of pharmacological sensitivity by KCNQ potassium channels

Haibo Yu, Zhihong Lin, Margrith E. Mattmann, +9

Proceedings of the National Academy of Sciences

Four basic residues critical for the ion selectivity and pore blocker sensitivity of TMEM16A calcium-activated chloride channels

Christian J. Peters, Haibo Yu, Jason Tien, +2

Proceedings of the National Academy of Sciences

Identification of (R)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide, ML277, as a novel, potent and selective Kv7.1 (KCNQ1) potassium channel activator

Margrith E. Mattmann, Haibo Yu, Zhihong Lin, +10

Bioorganic & Medicinal Chemistry Letters

Potassium Channel ActivatorBiochemistryMedicineSelective Kv7.1Ion Channels +3

Discovery, Synthesis, and Structure–Activity Relationship of a Series of <i>N</i>-Aryl-bicyclo[2.2.1]heptane-2-carboxamides: Characterization of ML213 as a Novel KCNQ2 and KCNQ4 Potassium Channel Opener

Haibo Yu, Meng Wu, Steven D. Townsend, +6

ACS Chemical Neuroscience

Structure–activity RelationshipNeurotransmitterOrganic ChemistryNeurotransmissionChemistry +17

Modulation of hERG potassium channel gating normalizes action potential duration prolonged by dysfunctional KCNQ1 potassium channel

Hongkang Zhang, Beiyan Zou, Haibo Yu, +10

Proceedings of the National Academy of Sciences

hERGCentral: A Large Database to Store, Retrieve, and Analyze Compound-Human <i>Ether-à-go-go</i> Related Gene Channel Interactions to Facilitate Cardiotoxicity Assessment in Drug Development

Fang Du, Haibo Yu, Beiyan Zou, +2

Assay and Drug Development Technologies

Discovery of [1,2,4]-triazolo [1,5-a]pyrimidine-7(4H)-one derivatives as positive modulators of GABAA1 receptor with potent anticonvulsant activity and low toxicity

Longjiang Huang, Jing Ding, Min Li, +4

European Journal of Medicinal Chemistry

Medicinal ChemistryLow ToxicityBiochemistryMedicineNatural Sciences +8

Phosphatidylinositol 4,5-bisphosphate alters pharmacological selectivity for epilepsy-causing KCNQ potassium channels

Pingzheng Zhou, Haibo Yu, Min Ji Gu, +3

Proceedings of the National Academy of Sciences