Concepedia

Identification of (R)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide, ML277, as a novel, potent and selective Kv7.1 (KCNQ1) potassium channel activator

Margrith E. Mattmann, Haibo Yu, Zhihong Lin, Kaiping Xu, Xiaofang Huang, Shunyou Long, Meng Wu, Owen B. McManus, Darren W. Engers, Uyen Le,

Bioorganic & Medicinal Chemistry Letters · 2012 · 71 citations · 6 references

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Concepts

References

6

Coassembly of KVLQT1 and minK (IsK) proteins to form cardiac IKS potassium channel

Michael C. Sanguinetti, Mark Curran, Anruo Zou et al. · Nature · 1996 · 1.8K citations

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A Novel Benzodiazepine that Activates Cardiac Slow Delayed Rectifier K+ Currents

Joseph J. Salata, Nancy K. Jurkiewicz, Jixin Wang et al. · Molecular Pharmacology · 1998 · 159 citations

, , +17

Stilbenes and fenamates rescue the loss of IKS channel function induced by an LQT5 mutation and other IsK mutants

I. Abitbol · The EMBO Journal · 1999 · 97 citations

, , +14

Discovery of a Novel Activator of KCNQ1-KCNE1 K+ Channel Complexes

K Mruk, William R. Kobertz · PLoS ONE · 2009 · 44 citations · Full text

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Desensitization of Chemical Activation by Auxiliary Subunits

Zhaobing Gao, Qiaojie Xiong, Haiyan Sun et al. · Journal of Biological Chemistry · 2008 · 40 citations · Full text

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