Uyen Le

Identification of (R)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide, ML277, as a novel, potent and selective Kv7.1 (KCNQ1) potassium channel activator

Margrith E. Mattmann, Haibo Yu, Zhihong Lin et al. · Bioorganic & Medicinal Chemistry Letters · 2012 · 71 citations · Full text

Natural Sciences, Medicinal Chemistry, Pharmacology +14

Positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4). Part II: Challenges in hit-to-lead

Richard D. Williams, Colleen M. Niswender, Qingwei Luo et al. · Bioorganic & Medicinal Chemistry Letters · 2008 · 58 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16

Discovery, Synthesis, and Structure−Activity Relationship Development of a Series of <i>N</i>-(4-Acetamido)phenylpicolinamides as Positive Allosteric Modulators of Metabotropic Glutamate Receptor 4 (mGlu₄) with CNS Exposure in Rats

Darren W. Engers, Julie R. Field, Uyen Le et al. · Journal of Medicinal Chemistry · 2011 · 48 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +16

Discovery of N-(4-methoxy-7-methylbenzo[d]thiazol-2-yl)isonicatinamide, ML293, as a novel, selective and brain penetrant positive allosteric modulator of the muscarinic 4 (M4) receptor

James M. Salovich, Paige N. Vinson, Douglas J. Sheffler et al. · Bioorganic & Medicinal Chemistry Letters · 2012 · 44 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +13

Discovery of a selective M4 positive allosteric modulator based on the 3-amino-thieno[2,3-b]pyridine-2-carboxamide scaffold: Development of ML253, a potent and brain penetrant compound that is active in a preclinical model of schizophrenia

Uyen Le, Bruce J. Melancon, Thomas M. Bridges et al. · Bioorganic & Medicinal Chemistry Letters · 2012 · 41 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16