James M. Salovich

Identification of ML204, a Novel Potent Antagonist That Selectively Modulates Native TRPC4/C5 Ion Channels

Melissa Miller, Jie Shi, Yingmin Zhu et al. · Journal of Biological Chemistry · 2011 · 208 citations · Full text

Discovery of Potent 2-Aryl-6,7-dihydro-5 <i>H</i> -pyrrolo[1,2- <i>a</i> ]imidazoles as WDR5-WIN-Site Inhibitors Using Fragment-Based Methods and Structure-Based Design

Feng Wang, Kyu Ok Jeon, James M. Salovich et al. · Journal of Medicinal Chemistry · 2018 · 67 citations · Full text

Discovery and Structure-Based Optimization of Benzimidazole-Derived Activators of SOS1-Mediated Nucleotide Exchange on RAS

Timothy R. Hodges, Jason R. Abbott, Andrew J. Little et al. · Journal of Medicinal Chemistry · 2018 · 52 citations · Full text

Combinatorial Chemistry, Gtp-bound Ras, Molecular Biology +27

Discovery, Synthesis, and Preclinical Characterization of<i>N</i>-(3-Chloro-4-fluorophenyl)-1<i>H</i>-pyrazolo[4,3-<i>b</i>]pyridin-3-amine (VU0418506), a Novel Positive Allosteric Modulator of the Metabotropic Glutamate Receptor 4 (mGlu₄)

Darren W. Engers, Anna L. Blobaum, Rocco D. Gogliotti et al. · ACS Chemical Neuroscience · 2016 · 45 citations · Full text

Discovery of N-(4-methoxy-7-methylbenzo[d]thiazol-2-yl)isonicatinamide, ML293, as a novel, selective and brain penetrant positive allosteric modulator of the muscarinic 4 (M4) receptor

James M. Salovich, Paige N. Vinson, Douglas J. Sheffler et al. · Bioorganic & Medicinal Chemistry Letters · 2012 · 44 citations · Full text

Medicinal Chemistry, Drug Target, Biochemistry +11