Andrew J. Little

Fragment Optimization of Reversible Binding to the Switch II Pocket on KRAS Leads to a Potent, In Vivo Active KRAS ^G12C Inhibitor

Joachim Bröker, Alex G. Waterson, Chris A. Smethurst et al. · Journal of Medicinal Chemistry · 2022 · 81 citations · Full text

Pharmacy, Medicinal Chemistry, Oncology +16

Discovery and Structure-Based Optimization of Benzimidazole-Derived Activators of SOS1-Mediated Nucleotide Exchange on RAS

Timothy R. Hodges, Jason R. Abbott, Andrew J. Little et al. · Journal of Medicinal Chemistry · 2018 · 56 citations · Full text

Life Sciences, Medicinal Chemistry, Molecular Biology +16

High-throughput screening identifies small molecules that bind to the RAS:SOS:RAS complex and perturb RAS signaling

Michael C. Burns, Jennifer E. Howes, Qi Sun et al. · Analytical Biochemistry · 2018 · 48 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +16

Total Syntheses of Graphisin A and Sydowinin B

Andrew J. Little, John A. Porco · Organic Letters · 2012 · 26 citations

Natural Sciences, Chemistry, Medicinal Chemistry +6

Montmorillonite clay-catalyzed hetero-Diels–Alder reaction of 2,3-dimethyl-1,3-butadiene with benzaldehydes

Matthew R. Dintzner, Andrew J. Little, Massimo Pacilli et al. · Tetrahedron Letters · 2007 · 25 citations

Natural Sciences, Chemistry, Materials Science +10