Alex G. Waterson

Discovery of Small Molecules that Bind to K‐Ras and Inhibit Sos‐Mediated Activation

Qi Sun, Jason P. Burke, Jason Phan et al. · Angewandte Chemie International Edition · 2012 · 495 citations

Drug Target, Nmr Spectroscopy, Molecular Biology +22

Small-molecule inhibition of Wnt signaling through activation of casein kinase 1α

Curtis A. Thorne, Alison Hanson, Judsen Schneider et al. · Nature Chemical Biology · 2010 · 472 citations · Full text

Signal Transduction, Signaling Pathway, Molecular Pathway +11

Drugging an undruggable pocket on KRAS

Dirk Kessler, Michael Gmachl, Andreas Mantoulidis et al. · Proceedings of the National Academy of Sciences · 2019 · 415 citations · Full text

Discovery of Dabrafenib: A Selective Inhibitor of Raf Kinases with Antitumor Activity against B-Raf-Driven Tumors

Tara Rheault, John Stellwagen, George M. Adjabeng et al. · ACS Medicinal Chemistry Letters · 2013 · 253 citations · Full text

B-raf-driven Tumors, Antitumor Activity, Hyperactive Signaling +16

Approach for targeting Ras with small molecules that activate SOS-mediated nucleotide exchange

Michael C. Burns, Qi Sun, R. Nathan Daniels et al. · Proceedings of the National Academy of Sciences · 2014 · 187 citations · Full text