Discovery of Small Molecules that Bind to K‐Ras and Inhibit Sos‐Mediated Activation

Qi Sun, Jason P. Burke, Jason Phan, +6

Angewandte Chemie International Edition

Drug TargetNmr SpectroscopyMolecular BiologyMolecular PharmacologyFragment-based Screen +20

Drugging an undruggable pocket on KRAS

Dirk Kessler, Michael Gmachl, Andreas Mantoulidis, +39

Proceedings of the National Academy of Sciences

Interaction with WDR5 Promotes Target Gene Recognition and Tumorigenesis by MYC

Lance R. Thomas, Qingguo Wang, Brian C. Grieb, +14

Molecular Cell

Cell RegulationMedicineCancer GenomicsTumor SuppressorCancer Genetics +6

Structural Basis for the Substrate Specificity of Tobacco Etch Virus Protease

Jason Phan, Alexander Zdanov, A.G. Evdokimov, +6

Journal of Biological Chemistry

Approach for targeting Ras with small molecules that activate SOS-mediated nucleotide exchange

Michael C. Burns, Qi Sun, R. Nathan Daniels, +8

Proceedings of the National Academy of Sciences

Structure-based Design of High Affinity Peptides Inhibiting the Interaction of p53 with MDM2 and MDMX

Jason Phan, Zhenyu Li, Agnieszka Kasprzak, +4

Journal of Biological Chemistry

Displacement of WDR5 from Chromatin by a WIN Site Inhibitor with Picomolar Affinity

Erin R. Aho, Jing Wang, Rocco D. Gogliotti, +21

Cell Reports

Human Thymidylate Synthase Is in the Closed Conformation When Complexed with dUMP and Raltitrexed, an Antifolate Drug^,

Jason Phan, Sangita Koli, W. Minor, +3

Biochemistry

Similar modes of polypeptide recognition by export chaperones in flagellar biosynthesis and type III secretion

A.G. Evdokimov, Jason Phan, Joseph E. Tropea, +4

Nature Structural & Molecular Biology

Protein SecretionBiosynthesisBioorganic ChemistryBiochemistryBiochemical Taxonomy +6

Fragment-Based Screening of the Bromodomain of ATAD2

Mary J. Harner, Brian A. Chauder, Jason Phan, +1

Journal of Medicinal Chemistry

Fragment ScreenMolecular CharacterizationFragment HitsBiochemistryNmr Spectroscopy +10