Dirk Kessler

Drugging an undruggable pocket on KRAS

Dirk Kessler, Michael Gmachl, Andreas Mantoulidis et al. · Proceedings of the National Academy of Sciences · 2019 · 434 citations · Full text

Medicine, Molecular Biology, Oncology +15

Structure-Based Design of an in Vivo Active Selective BRD9 Inhibitor

Laetitia J. Martin, Manfred Koegl, Gerd Bader et al. · Journal of Medicinal Chemistry · 2016 · 224 citations · Full text

Pharmacy, Medicinal Chemistry, Oncology +13

Chemically Induced Degradation of the Oncogenic Transcription Factor BCL6

Nina Kerres, Steffen Steurer, Stefanie Schlager et al. · Cell Reports · 2017 · 206 citations · Full text

Medicine, Cancer Biology, Molecular Biology +11

Discovery of Novel Spiro[3<i>H</i>-indole-3,2′-pyrrolidin]-2(1<i>H</i>)-one Compounds as Chemically Stable and Orally Active Inhibitors of the MDM2–p53 Interaction

Andreas Gollner, Dorothea Rudolph, Heribert Arnhof et al. · Journal of Medicinal Chemistry · 2016 · 121 citations

Pharmacy, Medicinal Chemistry, Pharmacology +16

Intracellular Trapping of the Selective Phosphoglycerate Dehydrogenase (PHGDH) Inhibitor <b>BI-4924</b> Disrupts Serine Biosynthesis

Harald Weinstabl, Matthias Treu, Joerg Rinnenthal et al. · Journal of Medicinal Chemistry · 2019 · 87 citations · Full text

Pharmacy, Biochemistry, Medicinal Chemistry +15