Manfred Koegl

A Novel Ubiquitination Factor, E4, Is Involved in Multiubiquitin Chain Assembly

Manfred Koegl, Thorsten Hoppe, Stephan Schlenker et al. · Cell · 1999 · 1.1K citations

Novel Ubiquitination Factor, Protein Function, Biochemistry +6

BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design

William Farnaby, Manfred Koegl, Michael J. Roy et al. · Nature Chemical Biology · 2019 · 553 citations · Full text

Tumor Biology, Medicine, Natural Sciences +10

Drugging an undruggable pocket on KRAS

Dirk Kessler, Michael Gmachl, Andreas Mantoulidis et al. · Proceedings of the National Academy of Sciences · 2019 · 415 citations · Full text

Iterative Design and Optimization of Initially Inactive Proteolysis Targeting Chimeras (PROTACs) Identify VZ185 as a Potent, Fast, and Selective von Hippel–Lindau (VHL) Based Dual Degrader Probe of BRD9 and BRD7

Vittoria Zoppi, Scott J. Hughes, Chiara Maniaci et al. · Journal of Medicinal Chemistry · 2018 · 321 citations · Full text

Csk inhibition of c-Src activity requires both the SH2 and SH3 domains of Src.

Giulio Superti‐Furga, Stefano Fumagalli, Manfred Koegl et al. · The EMBO Journal · 1993 · 274 citations · Full text

C-src Activity, Molecular Regulation, Molecular Biology +16