Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

Sung Hee Um, Francesca Frigerio, Mitsuhiro Watanabe, +8

Nature

ObesityMetabolic SyndromeNutritionInsulin SensitivityMetabolic Disorder +9

<i>S6K1</i> ^−/− / <i>S6K2</i> ^−/− Mice Exhibit Perinatal Lethality and Rapamycin-Sensitive 5′-Terminal Oligopyrimidine mRNA Translation and Reveal a Mitogen-Activated Protein Kinase-Dependent S6 Kinase Pathway

Mario Pende, Sung Hee Um, Virginie Mieulet, +7

Molecular and Cellular Biology

The mTOR Inhibitor RAD001 Sensitizes Tumor Cells to DNA-Damaged Induced Apoptosis through Inhibition of p21 Translation

Iwan Beuvink, Anne Boulay, Stefano Fumagalli, +7

Cell

P21 TranslationTumor BiologyApoptosisCell DeathDna-damaged Induced Apoptosis +6

A target for Src in mitosis

Stefano Fumagalli, Nicholas F. Totty, J. Justin Hsuan, +1

Nature

Cell DivisionMedicineNatural SciencesMeiosisMolecular Biology +7

Csk inhibition of c-Src activity requires both the SH2 and SH3 domains of Src.

Giulio Superti‐Furga, Stefano Fumagalli, Manfred Koegl, +2

The EMBO Journal

C-src ActivityMolecular RegulationMolecular BiologyCellular PhysiologySignaling Pathway +14

Requirement for Src Family Protein Tyrosine Kinases in G ₂ for Fibroblast Cell Division

Serge Roche, Stefano Fumagalli, Sara A. Courtneidge

Science

Suprainduction of p53 by disruption of 40S and 60S ribosome biogenesis leads to the activation of a novel G2/M checkpoint

Stefano Fumagalli, Vasily V. Ivanenkov, Teng Teng, +1

Genes & Development

Novel G2/m CheckpointRibosome BiogenesisCell RegulationMedicineRibosomal Subunits +10

Loss of Tumor Suppressor RPL5/RPL11 Does Not Induce Cell Cycle Arrest but Impedes Proliferation Due to Reduced Ribosome Content and Translation Capacity

Teng Teng, Carol A. Mercer, Philip Hexley, +2

Molecular and Cellular Biology

Cell DeathCell ProliferationCell CycleCancer BiologyTumor Biology +18

The Human p62 cDNA Encodes Sam68 and Not the RasGAP-Associated p62 Protein

Peter Lock, Stefano Fumagalli, Paul Polakis, +2

Cell

Molecular PhysiologyRasgap-associated P62 ProteinGeneticsGene ExpressionMedicine +2

EFL1 mutations impair eIF6 release to cause Shwachman-Diamond syndrome

Shengjiang Tan, Laëtitia Kermasson, Angela Hoslin, +18

Blood