Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation

Mitsuhiro Watanabe, Sander M. Houten, Chikage Mataki, +10

Nature

Metabolic SyndromeNutritionEnergy MetabolismBile AcidsEnergy Homeostasis +10

Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

Sung Hee Um, Francesca Frigerio, Mitsuhiro Watanabe, +8

Nature

ObesityMetabolic SyndromeNutritionInsulin SensitivityMetabolic Disorder +9

Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c

Mitsuhiro Watanabe, Sander M. Houten, Li Wang, +5

Journal of Clinical Investigation

Activation of peroxisome proliferator-activated receptor δ induces fatty acid β-oxidation in skeletal muscle and attenuates metabolic syndrome

Toshiya Tanaka, Joji Yamamoto, Satoshi Iwasaki, +19

Proceedings of the National Academy of Sciences

Loss of Claudin-15, but Not Claudin-2, Causes Na+ Deficiency and Glucose Malabsorption in Mouse Small Intestine

Atsushi Tamura, Hisayoshi Hayashi, Mitsunobu Imasato, +7

Gastroenterology

NutritionMetabolic SyndromeSodium HomeostasisDiabetesPhysiology +10

Lowering Bile Acid Pool Size with a Synthetic Farnesoid X Receptor (FXR) Agonist Induces Obesity and Diabetes through Reduced Energy Expenditure

Mitsuhiro Watanabe, Yasushi Horai, Sander M. Houten, +9

Journal of Biological Chemistry

ObesityMetabolic SyndromeBody CompositionBiliary TractAgonist Induces Obesity +7

Lithocholic acid, a bacterial metabolite reduces breast cancer cell proliferation and aggressiveness

Edit Mikó, András Vida, Tündé Kovàcs, +18

Biochimica et Biophysica Acta (BBA) - Bioenergetics

Serum bile acid along with plasma incretins and serum high–molecular weight adiponectin levels are increased after bariatric surgery

Hiroshi Nakatani, Kazunori Kasama, Takashi Oshiro, +3

Metabolism

ObesityMetabolic SyndromeBariatric SurgeryBiliary TractGastric Bypass +6

TGR5 potentiates GLP-1 secretion in response to anionic exchange resins

Taoufiq Harach, Thijs W.H. Pols, Mitsunori Nomura, +4

Scientific Reports

Bile acids induce monocyte differentiation toward interleukin‐12 hypo‐producing dendritic cells via a TGR5‐dependent pathway

Riko Ichikawa, Tetsuro Takayama, Kazuaki Yoneno∥, +9

Immunology

Innate Immune SystemImmunologyImmune RegulationImmunologic MechanismInnate Immunity +20