Activation of peroxisome proliferator-activated receptor δ induces fatty acid β-oxidation in skeletal muscle and attenuates metabolic syndrome

Toshiya Tanaka, Joji Yamamoto, Satoshi Iwasaki, +19

Proceedings of the National Academy of Sciences

PPARγ coactivator 1β/ERR ligand 1 is an ERR protein ligand, whose expression induces a high-energy expenditure and antagonizes obesity

Yasutomi Kamei, Hiroshi Ohizumi, Yasushi Fujitani, +7

Proceedings of the National Academy of Sciences

Synergy between LRH-1 and β-Catenin Induces G1 Cyclin-Mediated Cell Proliferation

Oronza A. Botrugno, Elisabeth Fayard, Jean‐Sébastien Annicotte, +8

Molecular Cell

Signal TransductionSignaling PathwayCell RegulationCell InteractionCell Proliferation +6

Dynamic Change of Chromatin Conformation in Response to Hypoxia Enhances the Expression of GLUT3 (SLC2A3) by Cooperative Interaction of Hypoxia-Inducible Factor 1 and KDM3A

Imari Mimura, Masaomi Nangaku, Yasuharu Kanki, +17

Molecular and Cellular Biology

GeneticsMolecular BiologyEpigeneticsOxidative StressTranscriptional Regulation +23

H3K4/H3K9me3 Bivalent Chromatin Domains Targeted by Lineage-Specific DNA Methylation Pauses Adipocyte Differentiation

Yoshihiro Matsumura, Ryo Nakaki, Takeshi Inagaki, +12

Molecular Cell

Histone ModificationsChromatinChromatin StructureChromatin RemodelingNatural Sciences +10

The Peroxisome Proliferator-Activated Receptor γ/Retinoid X Receptor α Heterodimer Targets the Histone Modification Enzyme PR-Set7/Setd8 Gene and Regulates Adipogenesis through a Positive Feedback Loop

Ken‐ichi Wakabayashi, Masashi Okamura, Shuichi Tsutsumi, +10

Molecular and Cellular Biology

Histone ModificationsMolecular RegulationEpigenetic ChangeGeneticsMetabolic Remodeling +22

Dysregulated expression of P1 and P2 promoter‐driven hepatocyte nuclear factor‐4α in the pathogenesis of human cancer

Toshiya Tanaka, Shuying Jiang, Hiromitsu Hotta, +20

The Journal of Pathology

Obesity and metabolic syndrome in histone demethylase JHDM2a‐deficient mice

Takeshi Inagaki, Makoto Tachibana, Kenta Magoori, +7

Genes to Cells

Histone ModificationsHistone H3Metabolic DisorderEpigenetic ChangeMetabolic Remodeling +23

A Comparison of Differences in the Gene Expression Profiles of Phorbol 12-myristate 13-acetate Differentiated THP-1 Cells and Human Monocyte-derived Macrophage

Takahide Kohro, Toshiya Tanaka, Takeshi Murakami, +4

Journal of Atherosclerosis and Thrombosis

ImmunologyImmune RegulationImmunologic MechanismGene Expression ProfilesCellular Physiology +15

COUP-TFII acts downstream of Wnt/β-catenin signal to silence PPARγ gene expression and repress adipogenesis

Masashi Okamura, Hiromi Kudo, Ken‐ichi Wakabayashi, +13

Proceedings of the National Academy of Sciences

Transcriptional RegulationSignaling PathwayLocal ChromatinPparγ Gene ExpressionMetabolic Signaling +16