Concepedia

Scott J. Hughes

SJ

15

Publications

1.8K

Citations

13

H-Index

1992

Active since

Affiliations

University of Dundee(Current)

Promega (United States)

Tulane University

Roche (Switzerland)

MRC Protein Phosphorylation and Ubiquitylation Unit

Scott J. Hughes is an author at University of Dundee specializing in biochemistry, molecular biology, and natural sciences.

Top concepts

BiochemistryNatural SciencesMolecular BiologyMedicineChemical BiologyProtein FoldingProtein AssemblyProtein DegradationProteomicsCell Biology

Publications per year

1992–2022

15

Publications

15

SPR-Measured Dissociation Kinetics of PROTAC Ternary Complexes Influence Target Degradation Rate

Michael J. Roy, Sandra Winkler, Scott J. Hughes et al. · ACS Chemical Biology · 2019 · 358 citations · Full text

Iterative Design and Optimization of Initially Inactive Proteolysis Targeting Chimeras (PROTACs) Identify VZ185 as a Potent, Fast, and Selective von Hippel–Lindau (VHL) Based Dual Degrader Probe of BRD9 and BRD7

Vittoria Zoppi, Scott J. Hughes, Chiara Maniaci et al. · Journal of Medicinal Chemistry · 2018 · 321 citations · Full text

Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation

Chiara Maniaci, Scott J. Hughes, Andrea Testa et al. · Nature Communications · 2017 · 234 citations · Full text

Trivalent PROTACs enhance protein degradation via combined avidity and cooperativity

Satomi Imaide, Kristin M. Riching, Nikolai Makukhin et al. · Nature Chemical Biology · 2021 · 225 citations · Full text

Protein Chemistry, Protein Function, Biochemistry +5

Structure‐Based Design of a Macrocyclic PROTAC

Andrea Testa, Scott J. Hughes, Xavier Lucas et al. · Angewandte Chemie International Edition · 2019 · 224 citations · Full text

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