Scott J. Hughes - Concepedia

Author

Scott J. Hughes

University of Dundee ORCID

Also Known As

D Shang, S.J. Hughes, Scott Hughes, Scott J Hughes, Scott J. Hughes, Scott J. Hughes (2657110), Scott J. Hughes

Publications

2.2K

Citations

H-Index

Concepts

All Affiliations

University of Dundee Promega (United States)Tulane University Roche (Switzerland)MRC Protein Phosphorylation and Ubiquitylation Unit

About

Scott J. Hughes is an author at University of Dundee specializing in biochemistry, molecular biology, and natural sciences.

Top Concepts

#	Concept	H-Index	Publications	Citations
1	Biochemistry	9	9	595
2	Natural Sciences	7	7	554
3	Medicine	6	6	255
4	Cell Biology	2	2	56
5	Cellular Physiology	1	1	26

Scott J. Hughes

Publications

1.8K

Citations

H-Index

Page 1

	Year	Citations
SPR-Measured Dissociation Kinetics of PROTAC Ternary Complexes Influence Target Degradation Rate Michael J. Roy, Sandra Winkler, Scott J. Hughes, ACS Chemical Biology	2019	358
Iterative Design and Optimization of Initially Inactive Proteolysis Targeting Chimeras (PROTACs) Identify VZ185 as a Potent, Fast, and Selective von Hippel–Lindau (VHL) Based Dual Degrader Probe of BRD9 and BRD7 Vittoria Zoppi, Scott J. Hughes, Chiara Maniaci, Journal of Medicinal Chemistry	2018	321
Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation Chiara Maniaci, Scott J. Hughes, Andrea Testa, Nature Communications	2017	234
Trivalent PROTACs enhance protein degradation via combined avidity and cooperativity Satomi Imaide, Kristin M. Riching, Nikolai Makukhin, Nature Chemical Biology Protein ChemistryProtein FunctionBiochemistryProtein AssemblyProtein Folding	2021	225
Structure‐Based Design of a Macrocyclic PROTAC Andrea Testa, Scott J. Hughes, Xavier Lucas, Angewandte Chemie International Edition	2019	224
Understanding and Improving the Membrane Permeability of VH032-Based PROTACs Victoria G. Klein, Chad E. Townsend, Andrea Testa, ACS Medicinal Chemistry Letters Proteinlipid InteractionMolecular BiologyMembrane CharacterizationVh032-based ProtacsLipophilic Permeability Efficiency	2020	129
Functional E3 ligase hotspots and resistance mechanisms to small-molecule degraders Alexander Hanzl, Ryan Casement, Hana Imrichová, Nature Chemical Biology Protein AssemblyBiochemistryProtein FoldingNatural SciencesMolecular Regulation	2022	103
Structure‐Based Design of a Macrocyclic PROTAC Andrea Testa, Scott J. Hughes, Xavier Lucas, Angewandte Chemie Molecular BiologyPeptide ScienceBet ProteinsChemistryAnalytical Ultracentrifugation	2019	35
Probing the ATP Site of GRP78 with Nucleotide Triphosphate Analogs Scott J. Hughes, T. Antoshchenko, Yun Chen, PLoS ONE Atpase DomainProteinlipid InteractionCell-surface Grp78Molecular BiologyCell Death	2016	30
Adenosine A1 receptor activation modulates human equilibrative nucleoside transporter 1 (hENT1) activity via PKC-mediated phosphorylation of serine-281 Scott J. Hughes, Xenia Cravetchi, Gonzalo L. Vilas, Cellular Signalling Molecular PharmacologySignal TransductionMolecular PhysiologyBiochemistryMolecular Pathway	2015	26

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