Kristin M. Riching

Iterative Design and Optimization of Initially Inactive Proteolysis Targeting Chimeras (PROTACs) Identify VZ185 as a Potent, Fast, and Selective von Hippel–Lindau (VHL) Based Dual Degrader Probe of BRD9 and BRD7

Vittoria Zoppi, Scott J. Hughes, Chiara Maniaci et al. · Journal of Medicinal Chemistry · 2018 · 321 citations · Full text

Quantitative Live-Cell Kinetic Degradation and Mechanistic Profiling of PROTAC Mode of Action

Kristin M. Riching, Sarah D. Mahan, Cesear Corona et al. · ACS Chemical Biology · 2018 · 305 citations · Full text

Trivalent PROTACs enhance protein degradation via combined avidity and cooperativity

Satomi Imaide, Kristin M. Riching, Nikolai Makukhin et al. · Nature Chemical Biology · 2021 · 225 citations · Full text

Protein Chemistry, Protein Function, Biochemistry +5

Discovery and resistance mechanism of a selective CDK12 degrader

Baishan Jiang, Yang Gao, Jianwei Che et al. · Nature Chemical Biology · 2021 · 131 citations · Full text

Signal Transduction, Natural Sciences, Receptor Tyrosine Kinase +5

Modeling the CRL4A ligase complex to predict target protein ubiquitination induced by cereblon-recruiting PROTACs

Nan Bai, Kristin M. Riching, Aman Makaju et al. · Journal of Biological Chemistry · 2022 · 78 citations · Full text

Protein Assembly, Molecular Biology, Target Protein Ubiquitination +20