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Trivalent PROTACs enhance protein degradation via combined avidity and cooperativity

Satomi Imaide, Kristin M. Riching, Nikolai Makukhin, Vesna Vetma, Claire Whitworth, Scott J. Hughes, Nicole Trainor, Sarah D. Mahan, Nancy E. Murphy, Angus D. Cowan,

Nature Chemical Biology · 2021 · 237 citations · 45 references

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45

Selective inhibition of BET bromodomains

P. Filippakopoulos, Jun Qi, S. Picaud et al. · Nature · 2010 · 4.3K citations · Full text

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Phthalimide conjugation as a strategy for in vivo target protein degradation

Georg E. Winter, Dennis L. Buckley, Joshiawa Paulk et al. · Science · 2015 · 1.7K citations

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Catalytic in vivo protein knockdown by small-molecule PROTACs

Daniel P. Bondeson, Alina Mares, Ian E. Smith et al. · Nature Chemical Biology · 2015 · 1.3K citations · Full text

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Structural basis of PROTAC cooperative recognition for selective protein degradation

Morgan S. Gadd, Andrea Testa, Xavier Lucas et al. · Nature Chemical Biology · 2017 · 1.2K citations · Full text

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Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4

Michael Zengerle, Kwok-Ho Chan, Alessio Ciulli · ACS Chemical Biology · 2015 · 1K citations · Full text

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