Kwok-Ho Chan

Structural basis of PROTAC cooperative recognition for selective protein degradation

Morgan S. Gadd, Andrea Testa, Xavier Lucas et al. · Nature Chemical Biology · 2017 · 1.2K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +13

Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4

Michael Zengerle, Kwok-Ho Chan, Alessio Ciulli · ACS Chemical Biology · 2015 · 1K citations · Full text

Medicine, Molecular Biology, Oncology +16

Trivalent PROTACs enhance protein degradation via combined avidity and cooperativity

Satomi Imaide, Kristin M. Riching, Nikolai Makukhin et al. · Nature Chemical Biology · 2021 · 237 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +9

Impact of Target Warhead and Linkage Vector on Inducing Protein Degradation: Comparison of Bromodomain and Extra-Terminal (BET) Degraders Derived from Triazolodiazepine (JQ1) and Tetrahydroquinoline (I-BET726) BET Inhibitor Scaffolds

Kwok-Ho Chan, Michael Zengerle, Andrea Testa et al. · Journal of Medicinal Chemistry · 2017 · 222 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

A bump-and-hole approach to engineer controlled selectivity of BET bromodomain chemical probes

Matthias G. J. Baud, Enrique Lin-Shiao, Teresa A.F. Cardote et al. · Science · 2014 · 148 citations

Life Sciences, Medicinal Chemistry, Molecular Biology +17