Concepedia

Andrea Testa

AT

28

Publications

3.8K

Citations

23

H-Index

2012

Active since

Affiliations

University of Dundee(Current)

MRC Protein Phosphorylation and Ubiquitylation Unit

Medical Research Council

University of Aberdeen

Promega (United States)

Andrea Testa is an author at University of Dundee specializing in natural sciences, biochemistry, and molecular biology.

Top concepts

Natural SciencesBiochemistryMolecular BiologyProtein FoldingMedicineProtein DegradationProteomicsChemical BiologyProtein AssemblyProtein Engineering

Publications per year

2012–2024

28

Publications

28

Structural basis of PROTAC cooperative recognition for selective protein degradation

Morgan S. Gadd, Andrea Testa, Xavier Lucas et al. · Nature Chemical Biology · 2017 · 1.1K citations · Full text

Protein Chemistry, Biochemistry, Protac Cooperative Recognition +10

Iterative Design and Optimization of Initially Inactive Proteolysis Targeting Chimeras (PROTACs) Identify VZ185 as a Potent, Fast, and Selective von Hippel–Lindau (VHL) Based Dual Degrader Probe of BRD9 and BRD7

Vittoria Zoppi, Scott J. Hughes, Chiara Maniaci et al. · Journal of Medicinal Chemistry · 2018 · 321 citations · Full text

Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation

Chiara Maniaci, Scott J. Hughes, Andrea Testa et al. · Nature Communications · 2017 · 234 citations · Full text

Trivalent PROTACs enhance protein degradation via combined avidity and cooperativity

Satomi Imaide, Kristin M. Riching, Nikolai Makukhin et al. · Nature Chemical Biology · 2021 · 225 citations · Full text

Protein Chemistry, Protein Function, Biochemistry +5

Structure‐Based Design of a Macrocyclic PROTAC

Andrea Testa, Scott J. Hughes, Xavier Lucas et al. · Angewandte Chemie International Edition · 2019 · 224 citations · Full text

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