Concepedia

Author

Andrea Testa

University of DundeeORCID

Also Known As

A. Testa, Andrea Testa, Testa, Andrea

79

Publications

4.2K

Citations

25

H-Index

32

Concepts

All Affiliations

University of DundeeMRC Protein Phosphorylation and Ubiquitylation UnitMedical Research CouncilUniversity of AberdeenPromega (United States)
AT

About

Andrea Testa is an author at University of Dundee specializing in natural sciences, biochemistry, and molecular biology.

Top Concepts

#ConceptH-IndexPublicationsCitations

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Natural Sciences

10

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1.7K

2

Biochemistry

9

9

1.7K

3

Medicine

6

6

1.4K

4

Engineering

2

2

40

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Biomolecular Engineering

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Andrea Testa

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28

Publications

3.8K

Citations

23

H-Index

YearCitations

Structural basis of PROTAC cooperative recognition for selective protein degradation

Morgan S. Gadd, Andrea Testa, Xavier Lucas,

Nature Chemical Biology

2017

1.1K

Iterative Design and Optimization of Initially Inactive Proteolysis Targeting Chimeras (PROTACs) Identify VZ185 as a Potent, Fast, and Selective von Hippel–Lindau (VHL) Based Dual Degrader Probe of BRD9 and BRD7

Vittoria Zoppi, Scott J. Hughes, Chiara Maniaci,

Journal of Medicinal Chemistry

2018

321

Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation

Chiara Maniaci, Scott J. Hughes, Andrea Testa,

Nature Communications

2017

234

Trivalent PROTACs enhance protein degradation via combined avidity and cooperativity

Satomi Imaide, Kristin M. Riching, Nikolai Makukhin,

Nature Chemical Biology

2021

225

Structure‐Based Design of a Macrocyclic PROTAC

Andrea Testa, Scott J. Hughes, Xavier Lucas,

Angewandte Chemie International Edition

2019

224

Impact of Target Warhead and Linkage Vector on Inducing Protein Degradation: Comparison of Bromodomain and Extra-Terminal (BET) Degraders Derived from Triazolodiazepine (JQ1) and Tetrahydroquinoline (I-BET726) BET Inhibitor Scaffolds

Kwok-Ho Chan, Michael Zengerle, Andrea Testa,

Journal of Medicinal Chemistry

2017

216

Targeted protein degradation via intramolecular bivalent glues

Oliver Hsia, Matthias Hinterndorfer, Angus D. Cowan,

Nature

2024

155

3-Fluoro-4-hydroxyprolines: Synthesis, Conformational Analysis, and Stereoselective Recognition by the VHL E3 Ubiquitin Ligase for Targeted Protein Degradation

Andrea Testa, Xavier Lucas, Guilherme V. Castro,

Journal of the American Chemical Society

2018

144

Rapid and Reversible Knockdown of Endogenously Tagged Endosomal Proteins via an Optimized HaloPROTAC Degrader

Hannah Tovell, Andrea Testa, Chiara Maniaci,

ACS Chemical Biology

2019

138

Sustained enzymatic activity and flow in crowded protein droplets

Andrea Testa, Mirco Dindo, Aleksander A. Rebane,

Nature Communications

2021

134

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