Concepedia

Chiara Maniaci

CM

11

Publications

1.4K

Citations

11

H-Index

2017

Active since

Affiliations

University of Dundee(Current)

MRC Protein Phosphorylation and Ubiquitylation Unit

Medical Research Council

Promega (United States)

Eisai (Japan)

Chiara Maniaci is an author at University of Dundee specializing in molecular biology, natural sciences, and protein degradation.

Top concepts

Protein FoldingNatural SciencesMolecular BiologyProtein DegradationMedicineBiochemistryProtein EngineeringProteomicsChemical BiologyProtein Assembly

Publications per year

2017–2024

11

Publications

11

Iterative Design and Optimization of Initially Inactive Proteolysis Targeting Chimeras (PROTACs) Identify VZ185 as a Potent, Fast, and Selective von Hippel–Lindau (VHL) Based Dual Degrader Probe of BRD9 and BRD7

Vittoria Zoppi, Scott J. Hughes, Chiara Maniaci et al. · Journal of Medicinal Chemistry · 2018 · 321 citations · Full text

Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation

Chiara Maniaci, Scott J. Hughes, Andrea Testa et al. · Nature Communications · 2017 · 234 citations · Full text

Trivalent PROTACs enhance protein degradation via combined avidity and cooperativity

Satomi Imaide, Kristin M. Riching, Nikolai Makukhin et al. · Nature Chemical Biology · 2021 · 225 citations · Full text

Protein Chemistry, Protein Function, Biochemistry +5

Targeted protein degradation via intramolecular bivalent glues

Oliver Hsia, Matthias Hinterndorfer, Angus D. Cowan et al. · Nature · 2024 · 155 citations · Full text

Rapid and Reversible Knockdown of Endogenously Tagged Endosomal Proteins via an Optimized HaloPROTAC Degrader

Hannah Tovell, Andrea Testa, Chiara Maniaci et al. · ACS Chemical Biology · 2019 · 138 citations · Full text

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