Concepedia

Morgan S. Gadd

MS

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Publications

11

Citations

2.4K

H-Index

11

Active since

2011

Affiliations

University of Dundee(Current)

The University of Sydney

Morgan S. Gadd is an author at University of Dundee specializing in life sciences, structural biology, and molecular biology.

ORCID

Publications per year

2011–2022

11

Publications

11

Structural basis of PROTAC cooperative recognition for selective protein degradation

Morgan S. Gadd, Andrea Testa, Xavier Lucas et al. · Nature Chemical Biology · 2017 · 1.2K citations · Full text

, , +13

Structure-Guided Design and Optimization of Small Molecules Targeting the Protein–Protein Interaction between the von Hippel–Lindau (VHL) E3 Ubiquitin Ligase and the Hypoxia Inducible Factor (HIF) Alpha Subunit with in Vitro Nanomolar Affinities

Carles Galdeano, Morgan S. Gadd, Pedro Soares et al. · Journal of Medicinal Chemistry · 2014 · 403 citations · Full text

, , +15

Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition

Julianty Frost, Carles Galdeano, Pedro Soares et al. · Nature Communications · 2016 · 245 citations · Full text

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Group-Based Optimization of Potent and Cell-Active Inhibitors of the von Hippel–Lindau (VHL) E3 Ubiquitin Ligase: Structure–Activity Relationships Leading to the Chemical Probe (2<i>S</i>,4<i>R</i>)-1-((<i>S</i>)-2-(1-Cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-<i>N</i>-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (VH298)

Pedro Soares, Morgan S. Gadd, Julianty Frost et al. · Journal of Medicinal Chemistry · 2017 · 163 citations · Full text

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Crystal Structure of the Cul2-Rbx1-EloBC-VHL Ubiquitin Ligase Complex

Teresa A.F. Cardote, Morgan S. Gadd, Alessio Ciulli · Structure · 2017 · 156 citations · Full text

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