Morgan S. Gadd

Structural basis of PROTAC cooperative recognition for selective protein degradation

Morgan S. Gadd, Andrea Testa, Xavier Lucas et al. · Nature Chemical Biology · 2017 · 1.1K citations · Full text

Protein Chemistry, Biochemistry, Protac Cooperative Recognition +10

Structure-Guided Design and Optimization of Small Molecules Targeting the Protein–Protein Interaction between the von Hippel–Lindau (VHL) E3 Ubiquitin Ligase and the Hypoxia Inducible Factor (HIF) Alpha Subunit with in Vitro Nanomolar Affinities

Carles Galdeano, Morgan S. Gadd, Pedro Soares et al. · Journal of Medicinal Chemistry · 2014 · 392 citations · Full text

Protein Function, Biochemistry, Natural Sciences +13

Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition

Julianty Frost, Carles Galdeano, Pedro Soares et al. · Nature Communications · 2016 · 233 citations · Full text

Group-Based Optimization of Potent and Cell-Active Inhibitors of the von Hippel–Lindau (VHL) E3 Ubiquitin Ligase: Structure–Activity Relationships Leading to the Chemical Probe (2<i>S</i>,4<i>R</i>)-1-((<i>S</i>)-2-(1-Cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-<i>N</i>-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (VH298)

Pedro Soares, Morgan S. Gadd, Julianty Frost et al. · Journal of Medicinal Chemistry · 2017 · 156 citations · Full text

Crystal Structure of the Cul2-Rbx1-EloBC-VHL Ubiquitin Ligase Complex

Teresa A.F. Cardote, Morgan S. Gadd, Alessio Ciulli · Structure · 2017 · 149 citations · Full text