Pedro Soares

Structure-Guided Design and Optimization of Small Molecules Targeting the Protein–Protein Interaction between the von Hippel–Lindau (VHL) E3 Ubiquitin Ligase and the Hypoxia Inducible Factor (HIF) Alpha Subunit with in Vitro Nanomolar Affinities

Carles Galdeano, Morgan S. Gadd, Pedro Soares et al. · Journal of Medicinal Chemistry · 2014 · 392 citations · Full text

Protein Function, Biochemistry, Natural Sciences +13

Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition

Julianty Frost, Carles Galdeano, Pedro Soares et al. · Nature Communications · 2016 · 233 citations · Full text

Group-Based Optimization of Potent and Cell-Active Inhibitors of the von Hippel–Lindau (VHL) E3 Ubiquitin Ligase: Structure–Activity Relationships Leading to the Chemical Probe (2<i>S</i>,4<i>R</i>)-1-((<i>S</i>)-2-(1-Cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-<i>N</i>-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (VH298)

Pedro Soares, Morgan S. Gadd, Julianty Frost et al. · Journal of Medicinal Chemistry · 2017 · 156 citations · Full text

Fine-tuning of the hydrophobicity of caffeic acid: studies on the antimicrobial activity against Staphylococcus aureus and Escherichia coli

Mafalda Andrade, Sofia Benfeito, Pedro Soares et al. · RSC Advances · 2015 · 73 citations · Full text

Antimicrobial Susceptibility, Potassium Leakage, Antibiotics +12

Development of a Mitochondriotropic Antioxidant Based on Caffeic Acid: Proof of Concept on Cellular and Mitochondrial Oxidative Stress Models

José Teixeira, Fernando Cagide, Sofia Benfeito et al. · Journal of Medicinal Chemistry · 2017 · 59 citations

Mitochondrial Oxidative Stress, Polyphenolics, Mitochondrial Function +14