Carles Galdeano

Structure-Guided Design and Optimization of Small Molecules Targeting the Protein–Protein Interaction between the von Hippel–Lindau (VHL) E3 Ubiquitin Ligase and the Hypoxia Inducible Factor (HIF) Alpha Subunit with in Vitro Nanomolar Affinities

Carles Galdeano, Morgan S. Gadd, Pedro Soares et al. · Journal of Medicinal Chemistry · 2014 · 403 citations · Full text

Life Sciences, Biochemistry, Medicinal Chemistry +15

Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition

Julianty Frost, Carles Galdeano, Pedro Soares et al. · Nature Communications · 2016 · 245 citations · Full text

Life Sciences, Medicinal Chemistry, Molecular Biology +14

Novel Donepezil-Based Inhibitors of Acetyl- and Butyrylcholinesterase and Acetylcholinesterase-Induced β-Amyloid Aggregation

Pelayo Camps, X. Formosa, Carles Galdeano et al. · Journal of Medicinal Chemistry · 2008 · 205 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17

Pyrano[3,2-<i>c</i>]quinoline−6-Chlorotacrine Hybrids as a Novel Family of Acetylcholinesterase- and β-Amyloid-Directed Anti-Alzheimer Compounds

Pelayo Camps, X. Formosa, Carles Galdeano et al. · Journal of Medicinal Chemistry · 2009 · 172 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +16

Group-Based Optimization of Potent and Cell-Active Inhibitors of the von Hippel–Lindau (VHL) E3 Ubiquitin Ligase: Structure–Activity Relationships Leading to the Chemical Probe (2<i>S</i>,4<i>R</i>)-1-((<i>S</i>)-2-(1-Cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-<i>N</i>-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (VH298)

Pedro Soares, Morgan S. Gadd, Julianty Frost et al. · Journal of Medicinal Chemistry · 2017 · 163 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +13