Julianty Frost

Hypoxia induces rapid changes to histone methylation and reprograms chromatin

Michael Batie, Julianty Frost, Mark Frost et al. · Science · 2019 · 393 citations

Life Sciences, Genetics, Molecular Biology +17

Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition

Julianty Frost, Carles Galdeano, Pedro Soares et al. · Nature Communications · 2016 · 245 citations · Full text

Life Sciences, Medicinal Chemistry, Molecular Biology +14

Group-Based Optimization of Potent and Cell-Active Inhibitors of the von Hippel–Lindau (VHL) E3 Ubiquitin Ligase: Structure–Activity Relationships Leading to the Chemical Probe (2<i>S</i>,4<i>R</i>)-1-((<i>S</i>)-2-(1-Cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-<i>N</i>-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (VH298)

Pedro Soares, Morgan S. Gadd, Julianty Frost et al. · Journal of Medicinal Chemistry · 2017 · 163 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +13

All human monocytes have the capability of expressing HLA-DQ and HLA-DP molecules upon stimulation with interferon-gamma.

Thomas A. Gonwa, Julianty Frost, Robert W. Karr · The Journal of Immunology · 1986 · 75 citations

Life Sciences, Cell Biology, Immunology +15

Gamma interferon and 5-azacytidine cause transcriptional elevation of class I major histocompatibility complex gene expression in K562 leukemia cells in the absence of differentiation.

E Chen, Robert W. Karr, Julianty Frost et al. · Molecular and Cellular Biology · 1986 · 46 citations

Life Sciences, Cell Biology, Molecular Biology +14